A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases.
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Collagenolytic Matrix Metalloproteinase Activities toward Peptomeric Triple-Helical SubstratesEngineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage.MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagenThe roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity.Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides.High-affinity peptide against MT1-MMP for in vivo tumor imagingBiochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinaseDirected evolution of protease beacons that enable sensitive detection of endogenous MT1-MMP activity in tumor cell lines.Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis.Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarctionCentrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis.FRET-based and other fluorescent proteinase probes.Using fluorogenic peptide substrates to assay matrix metalloproteinases.In vivo optical imaging of membrane-type matrix metalloproteinase (MT-MMP) activityMassively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13.Pressure overload-dependent membrane type 1-matrix metalloproteinase induction: relationship to LV remodeling and fibrosis.Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis.Identification of highly selective MMP-14 inhibitory Fabs by deep sequencing.Activatable and Cell-Penetrable Multiplex FRET Nanosensor for Profiling MT1-MMP Activity in Single Cancer Cells.Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase.Shedding of discoidin domain receptor 1 by membrane-type matrix metalloproteinases.Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences.Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach.Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cellsDevelopment of an optimized activatable MMP-14 targeted SPECT imaging probe.Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging.Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis.Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP): a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells.A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP.Chemical biology for understanding matrix metalloproteinase function.Mechanistic relationship between membrane type-1 matrix metalloproteinase and the myocardial response to pressure overload.Determining the Substrate Specificity of Matrix Metalloproteases using Fluorogenic Peptide Substrates.MMP-14 Triggered Fluorescence Contrast Agent.Development of Radiolabeled Membrane Type-1 Matrix Metalloproteinase Activatable Cell Penetrating Peptide Imaging Probes.Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability.Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity.Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease.
P2860
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P2860
A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
A unique substrate binding mod ...... her matrix metalloproteinases.
@en
A unique substrate binding mod ...... her matrix metalloproteinases.
@nl
type
label
A unique substrate binding mod ...... her matrix metalloproteinases.
@en
A unique substrate binding mod ...... her matrix metalloproteinases.
@nl
prefLabel
A unique substrate binding mod ...... her matrix metalloproteinases.
@en
A unique substrate binding mod ...... her matrix metalloproteinases.
@nl
P2093
P50
P356
P1476
A unique substrate binding mod ...... her matrix metalloproteinases.
@en
P2093
Boris I Ratnikov
Emily I Chen
Hisako Sawai
Jeffrey W Smith
Steven J Kridel
P304
23788-23793
P356
10.1074/JBC.M111574200
P407
P577
2002-04-16T00:00:00Z