Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. - Test2 - elhamkhani - TriplyDB

Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice.

Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice.

http://www.wikidata.org/entity/Q44486153

about

The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter Bile acid transporters in health and disease The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis Bile acid transporters Bile acids: regulation of synthesis Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes Recent advances in understanding and managing cholestasis The role of transporters in toxicity and disease Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine Role of the intestinal bile acid transporters in bile acid and drug disposition The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice In vivo performance of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile acid transport Bile acid flux is necessary for normal liver regeneration.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Green tea catechin EGCG inhibits ileal apical sodium bile acid transporter ASBT.Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice.Pathophysiological preconditions promoting mixed "black" pigment plus cholesterol gallstones in a DeltaF508 mouse model of cystic fibrosis.Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism.Synthesis and in vitro evaluation of potential sustained release prodrugs via targeting ASBT Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice.Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts.Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum Ileal apical Na+-dependent bile acid transporter ASBT is upregulated in rats with diabetes mellitus induced by low doses of streptozotocin.Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine.The farnesoid X receptor: a novel drug target?Cholesterol modulates human intestinal sodium-dependent bile acid transporter.Design and evaluation of a novel trifluorinated imaging agent for assessment of bile acid transport using fluorine magnetic resonance imaging.The mechanism of enterohepatic circulation in the formation of gallstone disease.Bile acid dysregulation, gut dysbiosis, and gastrointestinal cancer.The ileal lipid binding protein is required for efficient absorption and transport of bile acids in the distal portion of the murine small intestine.GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors Deciphering the nuclear bile acid receptor FXR paradigm.FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.In vivo magnetic resonance imaging to detect biliary excretion of 19F-labeled drug in mice Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver Functional characterization of genetic variants in the apical sodium-dependent bile acid transporter (ASBT; SLC10A2).

P2860

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P2860

Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice.

http://www.wikidata.org/entity/Q44486153

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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name

Targeted deletion of the ileal ...... cycling of bile acids in mice.

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Targeted deletion of the ileal ...... cycling of bile acids in mice.

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type

label

Targeted deletion of the ileal ...... cycling of bile acids in mice.

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Targeted deletion of the ileal ...... cycling of bile acids in mice.

@nl

prefLabel

Targeted deletion of the ileal ...... cycling of bile acids in mice.

@en

Targeted deletion of the ileal ...... cycling of bile acids in mice.

@nl

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Journal of Biological Chemistry

P1476

Targeted deletion of the ileal ...... cycling of bile acids in mice.

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P2093

Ann L Craddock

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Jamie Haywood

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John S Parks

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Kimberly Kluckman

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Martha Wilson

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Mary Tietjen

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Nobuyo Maeda

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Paul A Dawson

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P2860

Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)

Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity

Intestinal bile acid transport: biology, physiology, and pathophysiology

The enzymes, regulation, and genetics of bile acid synthesis

Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

The farnesoid X-receptor is an essential regulator of cholesterol homeostasis

Enhancement of jejunal absorption of conjugated bile acid by neurotensin in rats.

Dietary cholesterol and downregulation of cholesterol 7 alpha-hydroxylase and cholesterol absorption in African green monkeys.

Bile acid metabolism in hereditary forms of hypertriglyceridemia: evidence for an increased synthesis rate in monogenic familial hypertriglyceridemia.

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33920-33927

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10.1074/JBC.M306370200

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36

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278

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2003-06-20T00:00:00Z

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12819193

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