Inhibition and alternate substrate studies on the mechanism of carbapenam synthetase from Erwinia carotovora.
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Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesisCrystal structure of carbapenam synthetase (CarA)Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem AntibioticsConvergent biosynthetic pathways to β-lactam antibioticsFunctional specialization in proline biosynthesis of melanomaStructural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesisNon-heme iron oxygenases generate natural structural diversity in carbapenem antibioticsThe enzymes of β-lactam biosynthesis.Regulation and biosynthesis of carbapenem antibiotics in bacteria.Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.Origins of the β-lactam rings in natural products.Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase.A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis.A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase.Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics.Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetaseCarboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis.Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis.Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights.
P2860
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P2860
Inhibition and alternate substrate studies on the mechanism of carbapenam synthetase from Erwinia carotovora.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Inhibition and alternate subst ...... etase from Erwinia carotovora.
@en
Inhibition and alternate subst ...... etase from Erwinia carotovora.
@nl
type
label
Inhibition and alternate subst ...... etase from Erwinia carotovora.
@en
Inhibition and alternate subst ...... etase from Erwinia carotovora.
@nl
prefLabel
Inhibition and alternate subst ...... etase from Erwinia carotovora.
@en
Inhibition and alternate subst ...... etase from Erwinia carotovora.
@nl
P2093
P356
P1433
P1476
Inhibition and alternate subst ...... etase from Erwinia carotovora.
@en
P2093
Anthony Stapon
Barbara Gerratana
Craig A Townsend
P304
P356
10.1021/BI034361D
P407
P577
2003-07-01T00:00:00Z