Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas. - Test2 - elhamkhani - TriplyDB

Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas.

Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas.

http://www.wikidata.org/entity/Q44582765

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Molecular biology of lung cancer: clinical implications Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1 Structural basis for regulation of the Crk signaling protein by a proline switch.Oncogenic Signaling Adaptor Proteins PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway.Crk and CrkL are required for cell transformation by v-fos and v-ras.Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity.Crk at the quarter century mark: perspectives in signaling and cancer.Essential roles of Crk and CrkL in fibroblast structure and motility.Models of crk adaptor proteins in cancer.Domain cooperativity in multidomain proteins: what can we learn from molecular alignment in anisotropic media?Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma.Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation Proline cis-trans isomerization controls autoinhibition of a signaling protein.Protein fingerprints of anti-cancer effects of cyclin-dependent kinase inhibition: identification of candidate biomarkers using 2-D liquid phase separation coupled to mass spectrometry.CrkII transgene induces atypical mammary gland development and tumorigenesis.Molecular dynamics of the proline switch and its role in Crk signaling.CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas.Genetic susceptibility on CagA-interacting molecules and gene-environment interaction with phytoestrogens: a putative risk factor for gastric cancer.Emerging roles for crk in human cancer.Immunohistochemichal Assessment of the CrkII Proto-oncogene Expression in Common Malignant Salivary Gland Tumors and Pleomorphic Adenoma The Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-β in mammary epithelial cells An overview of lung cancer genomics and proteomics.Crk adaptor proteins act as key signaling integrators for breast tumorigenesis Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton.Activation of abl family kinases in solid tumors.Activated c-Abl tyrosine kinase in malignant solid tumors.Novel signaling collaboration between TGF-β and adaptor protein Crk facilitates EMT in human lung cancer.IFNs-signaling effects on lung cancer: an up-to-date pathways-specific review.The adaptor protein CrkII regulates IGF-1-induced biological behaviors of pancreatic ductal adenocarcinoma.The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer.Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL).Crk associates with ERM proteins and promotes cell motility toward hyaluronic acid.Crk II silencing down-regulates IGF-IR and inhibits migration and invasion of prostate cancer cells.c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells Crk and CrkL adaptor proteins: networks for physiological and pathological signaling

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Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas.

http://www.wikidata.org/entity/Q44582765

description

2003 nî lūn-bûn

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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name

Increased C-CRK proto-oncogene ...... otype in lung adenocarcinomas.

@en

Increased C-CRK proto-oncogene ...... otype in lung adenocarcinomas.

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type

label

Increased C-CRK proto-oncogene ...... otype in lung adenocarcinomas.

@en

Increased C-CRK proto-oncogene ...... otype in lung adenocarcinomas.

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prefLabel

Increased C-CRK proto-oncogene ...... otype in lung adenocarcinomas.

@en

Increased C-CRK proto-oncogene ...... otype in lung adenocarcinomas.

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Increased C-CRK proto-oncogene ...... otype in lung adenocarcinomas.

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Charles T Miller

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Dafydd G Thomas

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David E Misek

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David G Beer

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Guoan Chen

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Hong Wang

http://www.w3.org/2001/XMLSchema#string

John Yee

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Mark B Orringer

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Samir M Hanash

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Tarek G Gharib

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P2860

The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration.

A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation

Two species of human CRK cDNA encode proteins with distinct biological activities

Epithelial-mesenchymal transitions in tumour progression

A novel viral oncogene with structural similarity to phospholipase C

Tissue microarrays for high-throughput molecular profiling of tumor specimens

Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions.

Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers.

Crk family adaptors-signalling complex formation and biological roles.

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10.1038/SJ.ONC.1206529

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39

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22

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Thomas Giordano

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2003-09-01T00:00:00Z

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12970743

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