Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells.
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Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological TargetsStructural and Functional Relationships in the Virulence-associated Cathepsin L Proteases of the Parasitic Liver Fluke, Fasciola hepaticaCysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticityTegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycansApproaches for the identification of potential excreted/secreted proteins of Leishmania major parasites.Cathepsin B homologue at the interface between a parasitic nematode and its intermediate host.The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine proteaseMajor secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses.Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3.Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepaticaTowards delineating functions within the fasciola secreted cathepsin l protease family by integrating in vivo based sub-proteomics and phylogenetics.Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica.Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin BDroplet electrospray ionization mass spectrometry for high throughput screening for enzyme inhibitorsThe protein composition of the digestive fluid from the venus flytrap sheds light on prey digestion mechanisms.Comparative Transcriptomic Exploration Reveals Unique Molecular Adaptations of Neuropathogenic Trichobilharzia to Invade and Parasitize Its Avian Definitive Host.The diagnosis of human fascioliasis by enzyme-linked immunosorbent assay (ELISA) using recombinant cathepsin L protease.Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening.Induction of Protective Immune Responses Against Schistosomiasis haematobium in Hamsters and Mice Using Cysteine Peptidase-Based Vaccine.The highly antigenic 53/25 kDa Taenia solium protein fraction with cathepsin-L like activity is present in the oncosphere/cysticercus and induces non-protective IgG antibodies in pigsDevelopment of a multiplex fluorescence immunological assay for the simultaneous detection of antibodies against Cooperia oncophora, Dictyocaulus viviparus and Fasciola hepatica in cattleDetermining the Prevalence and Seasonality of Fasciola hepatica in Pasture-based Dairy herds in Ireland using a Bulk Tank Milk ELISA.Immunodiagnosis of Fasciola gigantica Infection Using Monoclonal Antibody-Based Sandwich ELISA and Immunochromatographic Assay for Detection of Circulating Cathepsin L1 ProteaseFasciola hepatica Surface Coat Glycoproteins Contain Mannosylated and Phosphorylated N-glycans and Exhibit Immune Modulatory Properties Independent of the Mannose ReceptorAdjuvant-enhanced antibody and cellular responses to inclusion bodies expressing FhSAP2 correlates with protection of mice to Fasciola hepaticaBulk milk ELISA and the diagnosis of parasite infections in dairy herds: a reviewAn integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host.Utility of a protein fraction with cathepsin L-Like activity purified from cysticercus fluid of Taenia solium in the diagnosis of human cysticercosisDevelopment of two antibody detection enzyme-linked immunosorbent assays for serodiagnosis of human chronic fascioliasis.Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.Blunting the knife: development of vaccines targeting digestive proteases of blood-feeding helminth parasites.Juvenile-specific cathepsin proteases in Fasciola spp.: their characteristics and vaccine efficacies.The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis.A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite.Molecular and immunological characterization of cathepsin L-like cysteine protease of Paragonimus pseudoheterotremus.Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases.Influence of levamisole and Freund's adjuvant on mouse immunisation with antigens of adults of the liver fluke Fasciola hepatica Linnaeus, 1758.Prevalence of liver fluke infection in Irish horses and assessment of a serological test for diagnosis of equine fasciolosis.Triclabendazole Effect on Protease Enzyme Activity in the Excretory- Secretory Products of Fasciola hepatica in Vitro.Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1.
P2860
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P2860
Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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name
Cathepsin L1, the major protea ...... reted from gastrodermal cells.
@en
Cathepsin L1, the major protea ...... reted from gastrodermal cells.
@nl
type
label
Cathepsin L1, the major protea ...... reted from gastrodermal cells.
@en
Cathepsin L1, the major protea ...... reted from gastrodermal cells.
@nl
prefLabel
Cathepsin L1, the major protea ...... reted from gastrodermal cells.
@en
Cathepsin L1, the major protea ...... reted from gastrodermal cells.
@nl
P2093
P2860
P50
P356
P1476
Cathepsin L1, the major protea ...... reted from gastrodermal cells.
@en
P2093
Angela Mousley
Colin M Stack
Gerard P Brennan
John P Dalton
Michael Stewart
Peter R Collins
Sandra M O'Neill
Thecla Ryan
P2860
P304
17038-17046
P356
10.1074/JBC.M308831200
P407
P577
2004-01-30T00:00:00Z