Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses.
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Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activityPulmonary fibrosis in response to environmental cues and molecular targets involved in its pathogenesisDelivery of bioactive lipids from composite microgel-microsphere injectable scaffolds enhances stem cell recruitment and skeletal repair.Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.The impact of sphingosine kinase-1 in head and neck cancer.Recent Advances of Curcumin in the Prevention and Treatment of Renal Fibrosis.Sphingosine 1-Phosphate Receptors: Do They Have a Therapeutic Potential in Cardiac Fibrosis?Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disordersCalcium-sensing receptor inhibits TGF-β-signaling by decreasing Smad2 phosphorylation.The immunosuppressant FTY720 (fingolimod) enhances glycosaminoglycan depletion in articular cartilage.Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage.Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levelsSphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degenerationSuramin inhibits renal fibrosis in chronic kidney disease.Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system.Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model.Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling.Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells.Pathogenesis of Systemic Sclerosis.TGFβ-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis.Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cellsThe ω3-polyunsaturated fatty acid derivatives AVX001 and AVX002 directly inhibit cytosolic phospholipase A(2) and suppress PGE(2) formation in mesangial cellsIntegrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome.Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling.Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer.Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signalingPotential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer.Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cellsSynergistic effect of bioactive lipid and condition medium on cardiac differentiation of human mesenchymal stem cells from different tissues.Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammationThe liaison between apoptotic cells and macrophages--the end programs the beginning.Sphingosine-1-phosphate receptor 3 influences cell cycle progression in muscle satellite cells.Lipid mediators in the neural cell nucleus: their metabolism, signaling, and association with neurological disorders.Noncanonical transforming growth factor beta signaling in scleroderma fibrosisSphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loopThe role of sphingolipid signalling in diabetes‑associated pathologies (Review).
P2860
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P2860
Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Sphingosine 1-phosphate cross- ...... r-beta-induced cell responses.
@en
Sphingosine 1-phosphate cross- ...... r-beta-induced cell responses.
@nl
type
label
Sphingosine 1-phosphate cross- ...... r-beta-induced cell responses.
@en
Sphingosine 1-phosphate cross- ...... r-beta-induced cell responses.
@nl
prefLabel
Sphingosine 1-phosphate cross- ...... r-beta-induced cell responses.
@en
Sphingosine 1-phosphate cross- ...... r-beta-induced cell responses.
@nl
P2093
P2860
P356
P1476
Sphingosine 1-phosphate cross- ...... r-beta-induced cell responses.
@en
P2093
Andrea Huwiler
Burkhardt Kleuser
Cuiyan Xin
Josef Pfeilschifter
Soheyla Shabahang
Wolfgang Eberhardt
P2860
P304
35255-35262
P356
10.1074/JBC.M312091200
P407
P577
2004-06-10T00:00:00Z