Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.
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Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stabilityComparative modelling of protein structure and its impact on microbial cell factories.Conformational transition pathway in the activation process of allosteric glucokinaseGCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: data from the J-MICC Study.Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis.Naturally occurring glucokinase mutations are associated with defects in posttranslational S-nitrosylation.Identification and functional characterisation of novel glucokinase mutations causing maturity-onset diabetes of the young in Slovakia.Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability.Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors.Whence cometh the allosterome?Discovery of a novel site regulating glucokinase activity following characterization of a new mutation causing hyperinsulinemic hypoglycemia in humansConformational transition pathway in the allosteric process of human glucokinase.Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation.Glucokinase activators in diabetes management.Solution NMR Spectroscopy for the Study of Enzyme Allostery.Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations.Mutational analysis of allosteric activation and inhibition of glucokinase.Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells.Model-Based Design of Biochemical Microreactors.Evidence-based tailoring of bioinformatics approaches to optimize methods that predict the effects of nonsynonymous amino acid substitutions in glucokinase.When is it MODY? Challenges in the Interpretation of Sequence Variants in MODY Genes.Susceptibility of glucokinase-MODY mutants to inactivation by oxidative stress in pancreatic β-cells.A unique hexokinase in Cryptosporidium parvum, an apicomplexan pathogen lacking the Krebs cycle and oxidative phosphorylation.Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPARα-Dependent AMPK Activation.The previously reported T342P GCK missense variant is not a pathogenic mutation causing MODY.Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future Perspectives.
P2860
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P2860
Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Insights into the structure an ...... y-onset diabetes of the young.
@en
Insights into the structure an ...... y-onset diabetes of the young.
@nl
type
label
Insights into the structure an ...... y-onset diabetes of the young.
@en
Insights into the structure an ...... y-onset diabetes of the young.
@nl
prefLabel
Insights into the structure an ...... y-onset diabetes of the young.
@en
Insights into the structure an ...... y-onset diabetes of the young.
@nl
P2093
P2860
P50
P356
P1476
Insights into the structure an ...... y-onset diabetes of the young.
@en
P2093
Amanda Stride
Anna M Steele
Carol Buettger
Chyio Shiota
Dorothy Zelent
Franz M Matschinsky
Giuseppe d'Annunzio
Harriet A J Castleden
Joseph Grimsby
P2860
P304
14105-14113
P356
10.1074/JBC.M413146200
P407
P50
P577
2005-01-25T00:00:00Z