about
WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signalingFZD recruits trimeric G-proteinsWNT:FZD complex promotes G-protein nucleotide exchangeG-protein subunits dissociate from WNT:FZD complexTranslocation and activation of PKC alpha in response to WNT signalingCalcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signalingTranslocation of NFATC1:CaN:CaM to nucleusDecreasing cGMP concentration promotes intracellular Ca2+ release in response to WNTG alpha t2 binds and activates PDE6Active calmodulin binds CAMK2PRKG is activated by binding to high levels of cGMP in the absence of WNT signalingAutophosphorylation and activation of CAMK2Dissociation of CaM and CAMK2 autophosphorylationCAMK2 binds MAP3K7Activation of MAP3K7 in response to WNTActivation of NLKNLK translocates to nucleusNLK phosphorylates TCF/LEFmiR-92b binds 3'UTR of NLK mRNANLK mRNA translation controlled by miR-92bTCF/LEF:CTNNB1 bind canonical WNT target promotersTranscription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEFPDE6 hydrolyses cGMP to GMP_R-HSA-4086398
P361
Q50298835-18C73CAC-2B16-4C37-B76B-4D0B8AD34681Q50298836-E3ECD7A7-BAF0-4A9C-B12E-FF4A1965F657Q50298837-95D35649-4E4D-4A7A-BE37-B26E0FDBC8D5Q50298838-23B48BD7-CACA-46CC-96A0-35652723CA5EQ50298839-4DB171E0-F27A-404C-8F2A-E0AAA63DA55AQ50298840-7C19065F-6314-47D6-ACB4-81F5D0F3CA1FQ50298841-DB707398-446C-426E-A6B0-79A7EF5DEAE7Q50298842-5E4DD002-3145-435B-A3E5-1A149D340B4AQ50298843-A565016A-1FAB-464C-B497-916F1791A28AQ50298845-9A657ED1-886E-4F42-8546-609E558AA46DQ50298846-9A9DC603-328A-4390-AC7A-24559FAF1BC4Q50298848-64ACB07D-0F49-43D5-B6E1-71C075FE4DD9Q50298849-47E75619-99B6-4C87-AA37-0B619EAC81D7Q50298850-002A7FC7-7ACC-4B18-A58C-D5860413D0EEQ50298851-8D4D4835-F316-4898-8B16-9DB8050708DEQ50298853-1C5B0D89-5ABE-4CD1-9674-4ECB5F4CC20FQ50298854-5AF8D772-05A8-4E87-AF7A-E2C8ADC49995Q50298855-DE9F09E4-D052-4071-A919-4B307B2C0605Q50298856-FF186558-26BF-468B-8EBE-CC2C2F8A90FBQ50298857-C15C9B1A-40F4-4F08-9379-AA62FF8790EBQ50298858-1183FF5E-91FF-4A67-977C-A934109DE35FQ50298859-1447BF1E-DB60-4B8B-9B7B-7BF0BF78F9A5Q56860758-AB2494DD-A58F-4B0E-B258-6930D4B8A918
P361
description
An instance of the biological pathway Ca2+ pathway in Homo sapiens
@en
name
Ca2+ pathway
@en
type
label
Ca2+ pathway
@en
prefLabel
Ca2+ pathway
@en
P2860
P527
P2860
P3937
R-HSA-4086398