about
Formal synthesis of (-)-kendomycin featuring a Prins-cyclization to construct the macrocycleSubstrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinaseSymmetric macrocycles by a Prins dimerization and macrocyclization strategy.Dual roles for cholesterol in mammalian cellsSilyl enol ether Prins cyclization: diastereoselective formation of substituted tetrahydropyran-4-onesSpecificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactionsTotal synthesis and structure assignment of (+)-hexacyclinol.A new in vivo cross-linking mass spectrometry platform to define protein-protein interactions in living cells.Determination of absolute configuration using kinetic resolution catalysts.Synthesis of two new enrichable and MS-cleavable cross-linkers to define protein-protein interactions by mass spectrometry.Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to TumorigenesisDesign of CID-cleavable protein cross-linkers: identical mass modifications for simpler sequence analysis.Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8.Mapping the structural topology of the yeast 19S proteasomal regulatory particle using chemical cross-linking and probabilistic modeling.Racemization in Prins cyclization reactionsDiastereoselective synthesis of the pectenotoxin 2 non-anomeric AB spiroacetal.Solvolysis of a tetrahydropyranyl mesylate: mechanistic implications for the Prins cyclization, 2-oxonia-cope rearrangement, and Grob fragmentation.Synthesis of the C1-C52 fragment of amphidinol 3, featuring a beta-alkoxy alkyllithium addition reaction.Synthesis and structural reassignment of (+)-epicalyxin F.A reductive cyclization approach to attenol AAssignment of absolute configuration to SCH 351448 via total synthesisDetermination of absolute configuration of secondary alcohols using thin-layer chromatographyDeveloping an Acidic Residue Reactive and Sulfoxide-Containing MS-Cleavable Homobifunctional Cross-Linker for Probing Protein-Protein Interactions.Cyclization via carbolithiation of alpha-amino alkyllithium reagents.A concise synthesis of ent-CholesterolPolyol synthesis with beta-oxyanionic alkyllithium reagents: syntheses of aculeatins A, B, and D.DABO Boronates: Stable Heterocyclic Boronic Acid Complexes for Use in Suzuki-Miyaura Cross-Coupling Reactions.A unified approach to polyene macrolides: synthesis of candidin and nystatin polyols.Developing new isotope-coded mass spectrometry-cleavable cross-linkers for elucidating protein structures.Developing a Multiplexed Quantitative Cross-Linking Mass Spectrometry Platform for Comparative Structural Analysis of Protein Complexes.Generation, structure and reactivity of tertiary organolithium reagents.Nanomole-Scale Assignment and One-Use Kits for Determining the Absolute Configuration of Secondary Alcohols.Allyl transfer to aldehydes and ketones by Brønsted acid activation of allyl and crotyl 1,3,2-dioxazaborolidines.Trianion synthon approach to spirocyclic heterocyclesRole of chirality in peptide-induced formation of cholesterol-rich domains.Concise synthesis of (+)-fastigiatine.Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.Distinct mechanisms underlying cholesterol protection against alcohol-induced BK channel inhibition and resulting vasoconstriction.Stereoselectivity and regioselectivity in the segment-coupling Prins cyclization.Prins Desymmetrization of a C(2)-Symmetric Diol: Application to the Synthesis of 17-Deoxyroflamycoin.
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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Scott D. Rychnovsky
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P106
P1153
7005152451
P21
P31
P496
0000-0002-7223-4389