about
The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populationsIFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell linesCathepsin H is an additional convertase of pro-granzyme BThe human interferon-inducible protein, IFI 16, is a repressor of transcriptionA cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytesCloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanomaIsotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicingNovel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16Granzymes: a family of lymphocyte granule serine proteasesHuman perforin mutations and susceptibility to multiple primary cancersThe major human and mouse granzymes are structurally and functionally divergentConformational changes during pore formation by the perforin-related protein pleurotolysinA common fold mediates vertebrate defense and bacterial attackThe structural basis for membrane binding and pore formation by lymphocyte perforinDefining the interaction of perforin with calcium and the phospholipid membranePerforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproductionhScrib is a functional homologue of the Drosophila tumour suppressor ScribbleGenomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organizationGranzyme M mediates a novel form of perforin-dependent cell deathStructural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid MembranesIsolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I geneThe Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamiliesThe closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expressionA natural genetic variant of granzyme B confers lethality to a common viral infectionThe MACPF/CDC family of pore-forming toxins.Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosisFailed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?A new intracellular serine protease inhibitor expressed in the rat pituitary gland complexes with granzyme B.Cloning and characterisation of Ifi206: a new murine HIN-200 family member.Functional crosstalk between type I and II interferon through the regulated expression of STAT1.Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin.Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells.A fresh look at tumor immunosurveillance and immunotherapy.B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
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name
Joseph A Trapani
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Joseph A Trapani
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Joseph A Trapani
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Joseph A Trapani
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Joseph A Trapani
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Joseph A Trapani
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Joseph A Trapani
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Joseph A Trapani
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Joseph A Trapani
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Joseph A Trapani
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JA Trapani
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Joseph A. Trapani
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Joseph Trapani
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Joseph A Trapani
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Joseph A Trapani
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Joseph A Trapani
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Joseph A Trapani
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Joseph A Trapani
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P106
P21
P31
P496
0000-0003-0983-1532