about
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinaseThe t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathwayTLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis.Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinasesThe translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNAComprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomesAssociation of HLA Class I and Class II genes with bcr-abl transcripts in leukemia patients with t(9;22) (q34;q11)The Philadelphia chromosome in leukemogenesisKinase-independent mechanisms of resistance of leukemia stem cells to tyrosine kinase inhibitorsSystems genetics for drug target discoveryCurrent concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemiaAnimal models of leukemia: any closer to the real thing?Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft ModelsTransformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective HckBCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with CrklDevelopmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequenceExpression of cassini, a murine gamma-satellite sequence conserved in evolution, is regulated in normal and malignant hematopoietic cellsModels of crk adaptor proteins in cancer.The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.Progressive changes in the leukemogenic signaling in BCR/ABL-transformed cells.Bcr-Abl with an SH3 deletion retains the ability To induce a myeloproliferative disease in mice, yet c-Abl activated by an SH3 deletion induces only lymphoid malignancySignal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesisBCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cellsMolecular genetic aspects of human cancers: the 1993 Frank Rose Lecture.Imatinib mesylate (STI571) treatment in patients with chronic-phase chronic myelogenous leukaemia previously submitted to autologous stem cell transplantation.Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineageReciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment.Emerging drugs for chronic myeloid leukemia.Biology-driven cancer drug development: back to the futureMurine models of acute leukemia: important tools in current pediatric leukemia research.In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications.BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cellsGeneration of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia.AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutationsExpression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder.The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-AblAnalysis of the structural basis of specificity of inhibition of the Abl kinase by STI571.Biology and treatment of adult acute lymphoblastic leukemia
P2860
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P2860
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh
1990年學術文章
@zh-hant
name
Acute leukaemia in bcr/abl transgenic mice.
@en
Acute leukaemia in bcr/abl transgenic mice.
@nl
type
label
Acute leukaemia in bcr/abl transgenic mice.
@en
Acute leukaemia in bcr/abl transgenic mice.
@nl
prefLabel
Acute leukaemia in bcr/abl transgenic mice.
@en
Acute leukaemia in bcr/abl transgenic mice.
@nl
P2093
P356
P1433
P1476
Acute leukaemia in bcr/abl transgenic mice.
@en
P2093
Heisterkamp N
Pattengale PK
ten Hoeve J
P2888
P304
P356
10.1038/344251A0
P407
P577
1990-03-01T00:00:00Z
P6179
1010982966