Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats. - Test2 - elhamkhani - TriplyDB

Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats.

Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats.

http://www.wikidata.org/entity/Q46749922

about

Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands Identification and characterization of abeta1,3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeats O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily Turn It Down a Notch Role of glycosylation of Notch in development Role of glycans and glycosyltransferases in the regulation of Notch signaling Fucosylation in prokaryotes and eukaryotes.Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.Protein O-fucosyltransferase 1 expression impacts myogenic C2C12 cell commitment via the Notch signaling pathway O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein).Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome.O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1.Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling.The N-acetyl-binding pocket of N-acetylglucosaminyltransferases also accommodates a sugar analog with a chemical handle at C2.Regulation of Notch signaling by glycosylation.Site-specific O-glucosylation of the epidermal growth factor-like (EGF) repeats of notch: efficiency of glycosylation is affected by proper folding and amino acid sequence of individual EGF repeats Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development.6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2.Lunatic fringe enhances competition for delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte beta-selection in vivo.MFng is dispensable for mouse pancreas development and function Role of unusual O-glycans in intercellular signaling A Notch updated.Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain.The Golgi apparatus: lessons from Drosophila.NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemia.Significance of glycosylation in Notch signaling.Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.The threonine that carries fucose, but not fucose, is required for Cripto to facilitate Nodal signaling.O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking.Structural and mechanistic insights into lunatic fringe from a kinetic analysis of enzyme mutants.Notch signalling stabilises boundary formation at the midbrain-hindbrain organiser.Deletion of Pofut1 in Mouse Skeletal Myofibers Induces Muscle Aging-Related Phenotypes in cis and in trans.Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats.O-fucosylation of an antibody light chain: characterization of a modification occurring on an IgG1 molecule.A Putative Protein O-Fucosyltransferase Facilitates Pollen Tube Penetration through the Stigma-Style Interface.

P2860

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P2860

Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats.

http://www.wikidata.org/entity/Q46749922

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Lunatic fringe, manic fringe, ...... al growth factor-like repeats.

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Lunatic fringe, manic fringe, ...... al growth factor-like repeats.

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type

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Lunatic fringe, manic fringe, ...... al growth factor-like repeats.

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Lunatic fringe, manic fringe, ...... al growth factor-like repeats.

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Lunatic fringe, manic fringe, ...... al growth factor-like repeats.

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Lunatic fringe, manic fringe, ...... al growth factor-like repeats.

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Journal of Biological Chemistry

P1476

Lunatic fringe, manic fringe, ...... al growth factor-like repeats.

@en

P2093

Aleksandra Nita-Lazar

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Annie S Y Li

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Daniel J Moloney

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Kelvin B Luther

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Raajit Rampal

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Robert S Haltiwanger

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Stephanie A Georgiou

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P2860

Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes

Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase

Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains

O-fucosylation of notch occurs in the endoplasmic reticulum

Notch signaling: cell fate control and signal integration in development

Fringe is a glycosyltransferase that modifies Notch

Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation

Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells

Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice

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42454-42463

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10.1074/JBC.M509552200

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280

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