Application of human FcRn transgenic mice as a pharmacokinetic screening tool of monoclonal antibody.
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Targeting FcRn for the modulation of antibody dynamicsPredicting pharmacokinetic profile of therapeutic antibodies after iv injection from only the data after sc injection in cynomolgus monkey.Mouse Models for Drug Discovery. Can New Tools and Technology Improve Translational Power?Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates.Utility of immunodeficient mouse models for characterizing the preclinical pharmacokinetics of immunogenic antibody therapeutics.Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies.Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization.A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.
P2860
Q28080589-B6CEFF75-7081-4920-9542-05D0FF49AB81Q31091923-D5E6DFFB-AFED-4FAC-BE41-834B937E71C2Q39161687-B783CA73-6635-4394-8BBF-BD1CE23F3520Q39277950-39C845E3-21DD-4006-A249-9F61ED7F7EF9Q39419756-36844678-FBEE-45F3-9F54-B31A701BD973Q39731345-735618C0-530E-4060-AF74-DD05246302B4Q42280832-A1F8207F-88D4-4707-BB59-98109920C4A4Q46242399-709780A9-341F-495E-9F59-9B220CE2DEFF
P2860
Application of human FcRn transgenic mice as a pharmacokinetic screening tool of monoclonal antibody.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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name
Application of human FcRn tran ...... g tool of monoclonal antibody.
@en
Application of human FcRn tran ...... g tool of monoclonal antibody.
@nl
type
label
Application of human FcRn tran ...... g tool of monoclonal antibody.
@en
Application of human FcRn tran ...... g tool of monoclonal antibody.
@nl
prefLabel
Application of human FcRn tran ...... g tool of monoclonal antibody.
@en
Application of human FcRn tran ...... g tool of monoclonal antibody.
@nl
P2093
P2860
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Application of human FcRn tran ...... ng tool of monoclonal antibody
@en
P2093
Masahiko Nanami
Masaki Ishigai
Tatsuhiko Tachibana
P2860
P304
P356
10.3109/00498254.2014.941963
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P50
P577
2014-07-17T00:00:00Z