about
Sos-mediated activation of rac1 by p66shcSIRT1 deacetylates APE1 and regulates cellular base excision repairInducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunctionP66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunctionElevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deathsTranscriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.Oxidant signaling in vascular cell growth, death, and survival : a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling.A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expressionHistone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase.Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain.Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc.SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthaseActivation of Stat3 in endothelial cells following hypoxia-reoxygenation is mediated by Rac1 and protein Kinase C.Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunctionAPE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer.Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor.Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosisVascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1.Protection from reoxygenation injury by inhibition of rac1.Redox regulation of human Rac1 stability by the proteasome in human aortic endothelial cells.MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.Signal transducer and activator of transcription 3alpha and specificity protein 1 interact to upregulate intercellular adhesion molecule-1 in ischemic-reperfused myocardium and vascular endothelium.P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc.Constitutive activation of rac1 results in mitochondrial oxidative stress and induces premature endothelial cell senescence.Bcl-2 regulates nonapoptotic signal transduction: inhibition of c-Jun N-terminal kinase (JNK) activation by IL-1 beta and hydrogen peroxide.A requirement for rac1 in the PDGF-stimulated migration of fibroblasts and vascular smooth cells.Rac1 is required for cell proliferation and G2/M progression.Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1.Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction.Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress.Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells.Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling.Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.p66(Shc) has a pivotal function in impaired liver regeneration in aged mice by a redox-dependent mechanism.Angiotensin II-stimulated vascular remodeling: the search for the culprit oxidase.Critical role of NADPH oxidase-derived reactive oxygen species in generating Ca2+ oscillations in human aortic endothelial cells stimulated by histamine.
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Kaikobad Irani
@ast
Kaikobad Irani
@en
Kaikobad Irani
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Kaikobad Irani
@nl
Kaikobad Irani
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type
label
Kaikobad Irani
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Kaikobad Irani
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Kaikobad Irani
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Kaikobad Irani
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Kaikobad Irani
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prefLabel
Kaikobad Irani
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Kaikobad Irani
@en
Kaikobad Irani
@es
Kaikobad Irani
@nl
Kaikobad Irani
@sl
P108
P106
P31
P496
0000-0001-9194-7387