A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.
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A role for phosphatidic acid in the formation of "supersized" lipid dropletsFld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast.DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytesHuman 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic.Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis.Genetic determinants of hepatic steatosis in man.Glycerophosphate/Acylglycerophosphate acyltransferases.Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity.Defective differentiation of adipose precursor cells from lipodystrophic mice lacking perilipin 1.Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signalingLipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis.Seipin: from human disease to molecular mechanismA role for 1-acylglycerol-3-phosphate-O-acyltransferase-1 in myoblast differentiation.Alterations in lipid signaling underlie lipodystrophy secondary to AGPAT2 mutations.Approaches to lipid metabolism gene identification and characterization in the postgenomic era.Lysophosphatidylcholine acyltransferase 3 is the key enzyme for incorporating arachidonic acid into glycerophospholipids during adipocyte differentiationIdentification and Characterisation of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2 : C48R: A Novel Mutation in AGPAT2.Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX): A Combinatorial Multimolecular Omics Approach for Systems Biology.The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation.Perilipin 1 moves between the fat droplet and the endoplasmic reticulumLipin1 regulates PPARγ transcriptional activity.Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis.AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue.The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1.Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesisMolecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy.Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis.Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis.Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3.The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation.Aralia cordata inhibits triacylglycerol biosynthesis in HepG2 cells.Divergent metabolic phenotype between two sisters with congenital generalized lipodystrophy due to double AGPAT2 homozygous mutations. a clinical, genetic and in silico study.Ginsenoside Rg1 suppresses early stage of adipocyte development via activation of C/EBP homologous protein-10 in 3T3-L1 and attenuates fat accumulation in high fat diet-induced obese zebrafish.Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice.Molecular mechanisms controlling human adipose tissue development: insights from monogenic lipodystrophies.Balancing the fat: lipid droplets and human disease.Congenital lipodystrophies and dyslipidemias.Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2.How lipid droplets "TAG" along: Glycerolipid synthetic enzymes and lipid storage.
P2860
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P2860
A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
A regulatory role for 1-acylgl ...... in adipocyte differentiation.
@en
A regulatory role for 1-acylgl ...... in adipocyte differentiation.
@nl
type
label
A regulatory role for 1-acylgl ...... in adipocyte differentiation.
@en
A regulatory role for 1-acylgl ...... in adipocyte differentiation.
@nl
prefLabel
A regulatory role for 1-acylgl ...... in adipocyte differentiation.
@en
A regulatory role for 1-acylgl ...... in adipocyte differentiation.
@nl
P2093
P2860
P356
P1476
A regulatory role for 1-acylgl ...... in adipocyte differentiation.
@en
P2093
Andrey Frolov
Daniel S Ory
Jean E Schaffer
Perry E Bickel
Sarah E Gale
Xianlin Han
P2860
P304
11082-11089
P356
10.1074/JBC.M509612200
P407
P577
2006-02-22T00:00:00Z