Evaluation of modafinil as a perpetrator of metabolic drug-drug interactions using a model informed cocktail reaction phenotyping trial protocol.

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Evaluation of modafinil as a perpetrator of metabolic drug-drug interactions using a model informed cocktail reaction phenotyping trial protocol.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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Evaluation of modafinil as a p ...... on phenotyping trial protocol.

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Evaluation of modafinil as a p ...... on phenotyping trial protocol.

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label

Evaluation of modafinil as a p ...... on phenotyping trial protocol.

@en

Evaluation of modafinil as a p ...... on phenotyping trial protocol.

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Evaluation of modafinil as a p ...... on phenotyping trial protocol.

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Evaluation of modafinil as a p ...... on phenotyping trial protocol.

@nl

P1476

Evaluation of modafinil as a p ...... on phenotyping trial protocol.

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P2093

Angela Rowland

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David Warncken

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Madelé van Dyk

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P2860

In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Drug interaction studies: study design, data analysis, and implications for dosing and labeling.

A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.

Modafinil augmentation of antidepressant treatment in depression.

Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials.

Single-dose pharmacokinetics of modafinil and methylphenidate given alone or in combination in healthy male volunteers.

Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring.

Cytochrome P450 structure-function: insights from molecular dynamics simulations.

Optimized Cocktail Phenotyping Study Protocol Using Physiological Based Pharmacokinetic Modeling and In silico Assessment of Metabolic Drug-Drug Interactions Involving Modafinil.

P304

501-509

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P31

scholarly article

P356

10.1111/BCP.13478

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

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P50

Michael J. Sorich

Arduino A Mangoni

Andrew Rowland

P577

2017-11-26T00:00:00Z

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P698

29178272

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P921

modafinil

P932

5809348

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