Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.
about
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetlesCrystal Structure of Baeyer−Villiger Monooxygenase MtmOIV, the Key Enzyme of the Mithramycin Biosynthetic Pathway,Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydraseCyclization of aromatic polyketides from bacteria and fungiDeoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity.Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus.Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novCrystallization and X-ray diffraction properties of Baeyer-Villiger monooxygenase MtmOIV from the mithramycin biosynthetic pathway in Streptomyces argillaceus.The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivityDimerization and DNA recognition rules of mithramycin and its analoguesGeneration of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.Evolution in action: dissemination of tet(X) into pathogenic microbiota.PKS and NRPS release mechanisms.Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycinEssential role of an activator protein-2 (AP-2)/specificity protein 1 (Sp1) cluster in the UVB-mediated induction of the human vascular endothelial growth factor in HaCaT keratinocytes.Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOIIMtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.Increased heterologous production of the antitumoral polyketide mithramycin A by engineered Streptomyces lividans TK24 strains.Manipulation of two regulatory genes for efficient production of chromomycins in Streptomyces reseiscleroticus.
P2860
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P2860
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Oxidative cleavage of premithr ...... he antitumor drug mithramycin.
@en
Oxidative cleavage of premithr ...... he antitumor drug mithramycin.
@nl
type
label
Oxidative cleavage of premithr ...... he antitumor drug mithramycin.
@en
Oxidative cleavage of premithr ...... he antitumor drug mithramycin.
@nl
prefLabel
Oxidative cleavage of premithr ...... he antitumor drug mithramycin.
@en
Oxidative cleavage of premithr ...... he antitumor drug mithramycin.
@nl
P2093
P1476
Oxidative cleavage of premithr ...... he antitumor drug mithramycin.
@en
P2093
Weissbach U
P356
10.1016/S1074-5521(99)80017-9
P577
1999-01-01T00:00:00Z