about
Identification of a gene cluster for antibacterial polyketide-derived antibiotic biosynthesis in the nystatin producer Streptomyces noursei ATCC 11455.Rational design of macrolides by virtual screening of combinatorial libraries generated through in silico manipulation of polyketide synthases.Identification of novel genes involved in long-chain n-alkane degradation by Acinetobacter sp. strain DSM 17874.Rare actinomycete bacteria from the shallow water sediments of the Trondheim fjord, Norway: isolation, diversity and biological activity.[Computer-aided design of polyketides with the required properties].Genomics of sponge-associated Streptomyces spp. closely related to Streptomyces albus J1074: insights into marine adaptation and secondary metabolite biosynthesis potential.Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents.Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis species.Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei.Structure-antifungal activity relationships of polyene antibiotics of the amphotericin B group.Polyene antibiotic biosynthesis gene clusters.Biosynthesis of deoxyaminosugars in antibiotic-producing bacteria.Minimum Information about a Biosynthetic Gene cluster.Cloning and Heterologous Expression of the Grecocycline Biosynthetic Gene Cluster.Complete genome sequence of the actinomycete Actinoalloteichus hymeniacidonis type strain HPA 177T isolated from a marine spongeMarine actinomycetes as an emerging resource for the drug development pipelines.Genome-based bioprospecting of microbes for new therapeutics.Alginate Biosynthesis Factories in Pseudomonas fluorescens: Localization and Correlation with Alginate Production Level.Development of a Biosensor Concept to Detect the Production of Cluster-Specific Secondary Metabolites.Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment.Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.Activation of chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712 by ethanol shock: insights from the promoter fusion studies.Identification of a methyl-specific restriction system mediated by a conjugative element from Streptomyces bambergiensis.Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.Identification of a New Phosphatase Enzyme Potentially Involved in the Sugar Phosphate Stress Response in Pseudomonas fluorescens.In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis.Actinomycetes from sediments in the Trondheim fjord, Norway: diversity and biological activity.Isolation and characterization of the gene cluster for biosynthesis of the thiopeptide antibiotic TP-1161.Insights into the evolution of macrolactam biosynthesis through cloning and comparative analysis of the biosynthetic gene cluster for a novel macrocyclic lactam, ML-449Characterization of the P450 monooxygenase NysL, responsible for C-10 hydroxylation during biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei.Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.Characterization of Streptomyces spp. isolated from the sea surface microlayer in the Trondheim Fjord, Norway.Synthesis and study of the antifungal activity of new mono- and disubstituted derivatives of a genetically engineered polyene antibiotic 28,29-didehydronystatin A1 (S44HP).Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin biosynthesis in Streptomyces noursei.Engineering terpene biosynthesis in Streptomyces for production of the advanced biofuel precursor bisabolene.Chemical modification and biological evaluation of new semisynthetic derivatives of 28,29-Didehydronystatin A1 (S44HP), a genetically engineered antifungal polyene macrolide antibiotic.Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.The linear Streptomyces plasmid pBL1: analyses of transfer functions.An unexpected role for the putative 4'-phosphopantetheinyl transferase-encoding gene nysF in the regulation of nystatin biosynthesis in Streptomyces noursei ATCC 11455.Hexaene derivatives of nystatin produced as a result of an induced rearrangement within the nysC polyketide synthase gene in S. noursei ATCC 11455.
P50
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P50
description
hulumtues
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հետազոտող
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name
Sergey B Zotchev
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Sergey B Zotchev
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Sergey B Zotchev
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Sergey B. Zotchev
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type
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Sergey B Zotchev
@es
Sergey B Zotchev
@nl
Sergey B Zotchev
@sl
Sergey B. Zotchev
@en
prefLabel
Sergey B Zotchev
@es
Sergey B Zotchev
@nl
Sergey B Zotchev
@sl
Sergey B. Zotchev
@en
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