Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
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RBM4 interacts with an intronic element and stimulates tau exon 10 inclusionSUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegansLRRK2 phosphorylates novel tau epitopes and promotes tauopathyIs tau ready for admission to the prion club?The pathobiology of splicingPresenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylationIdentification of novel murine- and human-specific RPGRIP1 splice variants with distinct expression profiles and subcellular localizationMutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 betaPin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?Drug Development in Alzheimer's Disease: The Contribution of PET and SPECTTau: The Center of a Signaling Nexus in Alzheimer's DiseaseCharacteristics of Tau and Its Ligands in PET ImagingTau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective StrategiesFrontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutationsAlzheimer's Disease: Mechanism and Approach to Cell TherapyRelevance of chronic stress and the two faces of microglia in Parkinson's diseaseTau-tubulin kinaseBrain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathiesMicrotubule-stabilizing agents as potential therapeutics for neurodegenerative diseaseDeveloping therapeutic approaches to tau, selected kinases, and related neuronal protein targetsTangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing ProblemThe role of tau in neurodegenerative diseases and its potential as a therapeutic targetAntisense oligonucleotides: treating neurodegeneration at the level of RNAInvited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimagingTau and tauopathiesDirect force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules.Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17Structural Basis for Stabilization of the Tau Pre-mRNA Splicing Regulatory Element by Novantrone (Mitoxantrone)The struggle by Caenorhabditis elegans to maintain proteostasis during aging and diseaseComparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's diseaseThe ubiquitin-proteasome system in Alzheimer's diseaseStaging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathyAge-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic miceGenotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tauCapzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowthOverexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neuronsPhosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathiesReduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutationsZebrafish models of Tauopathy
P2860
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P2860
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
@en
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
@nl
type
label
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
@en
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
@nl
prefLabel
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
@en
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
@nl
P2093
P1433
P1476
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
@en
P2093
Geschwind DH
Schellenberg GD
P304
P356
10.1126/SCIENCE.282.5395.1914
P407
P577
1998-12-01T00:00:00Z