Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes.
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Engraftment of nonintegrating neural stem cells differentially perturbs cortical activity in a dose-dependent manner.Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia.Elevated serotonergic signaling amplifies synaptic noise and facilitates the emergence of epileptiform network oscillations.Nardosinone improves the proliferation, migration and selective differentiation of mouse embryonic neural stem cells.Mapk/Erk activation in an animal model of social deficits shows a possible link to autism.Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation.EphA4 Regulates the Balance between Self-Renewal and Differentiation of Radial Glial Cells and Intermediate Neuronal Precursors in Cooperation with FGF Signaling.Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma.Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autismRAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunctionLayer specific and general requirements for ERK/MAPK signaling in the developing neocortexReceptor-interacting protein 140 overexpression promotes neuro-2a neuronal differentiation by ERK1/2 signaling.Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.Plasticity-related genes in brain development and amygdala-dependent learning.MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling.Prostaglandin E2 alters Wnt-dependent migration and proliferation in neuroectodermal stem cells: implications for autism spectrum disorders.Current understanding of methamphetamine-associated dopaminergic neurodegeneration and psychotoxic behaviors.Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.MEK Is a Key Regulator of Gliogenesis in the Developing Brain.Regulation of neural progenitor cell proliferation by D609: potential role for ERK.Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders.From peroxisomal disorders to common neurodegenerative diseases - the role of ether phospholipids in the nervous system.Chronic impairment of ERK signaling in glutamatergic neurons of the forebrain does not affect spatial memory retention and LTP in the same manner as acute blockade of the ERK pathway.A proteomic approach to understand MMP-3-driven developmental processes in the postnatal cerebellum: Chaperonin CCT6A and MAP kinase as contributing factors.CAPON-nNOS coupling can serve as a target for developing new anxiolytics.Differential Activation of Mitogen-Activated Protein Kinases, ERK 1/2, p38(MAPK) and JNK p54/p46 During Postnatal Development of Rat Hippocampus.Hypersensitivity of Prelimbic Cortex Neurons Contributes to Aggravated Nociceptive Responses in Rats With Experience of Chronic Inflammatory Pain.Mek1Y130C mice recapitulate aspects of human cardio-facio-cutaneous syndrome.
P2860
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P2860
Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Disrupted ERK signaling during ...... taneous and related syndromes.
@en
Disrupted ERK signaling during ...... taneous and related syndromes.
@nl
type
label
Disrupted ERK signaling during ...... taneous and related syndromes.
@en
Disrupted ERK signaling during ...... taneous and related syndromes.
@nl
prefLabel
Disrupted ERK signaling during ...... taneous and related syndromes.
@en
Disrupted ERK signaling during ...... taneous and related syndromes.
@nl
P2093
P1476
Disrupted ERK signaling during ...... taneous and related syndromes.
@en
P2093
Gary E Landreth
J Colleen Karlo
Joanna Pucilowska
Roberto F Galán
P304
P356
10.1523/JNEUROSCI.1107-12.2012
P407
P577
2012-06-01T00:00:00Z