Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity.
about
26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide.Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products.Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathwayThe proteasome activator 11 S REG (PA28) and class I antigen presentationThe specificity of proteasomes: impact on MHC class I processing and presentation of antigens.Immunoproteasome deficiency alters retinal proteasome's response to stressProteasome inhibitors: from in vitro uses to clinical trials.Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes.Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses.A novel role for the immunoproteasome in retinal function.On the role of proteasomes in cell biology and proteasome inhibition as a novel frontier in the development of immunosuppressants.Ongoing coxsackievirus myocarditis is associated with increased formation and activity of myocardial immunoproteasomesGeneration of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes.Roles of ubiquitination at the synapse.IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.LMP2-specific inhibitors: chemical genetic tools for proteasome biology.Binding of aflatoxins to the 20S proteasome: effects on enzyme functionality and implications for oxidative stress and apoptosis.A mathematical model of protein degradation by the proteasome.gamma-Interferon decreases the level of 26 S proteasomes and changes the pattern of phosphorylation.Mutational analysis of subunit i beta2 (MECL-1) demonstrates conservation of cleavage specificity between yeast and mammalian proteasomes.Inactivation of a defined active site in the mouse 20S proteasome complex enhances major histocompatibility complex class I antigen presentation of a murine cytomegalovirus protein.Redundancy of enzymes for formaldehyde detoxification in Pseudomonas putida.50 Hz extremely low frequency electromagnetic fields enhance protein carbonyl groups content in cancer cells: effects on proteasomal systems.Co-translational interactions of apoprotein B with the ribosome and translocon during lipoprotein assembly or targeting to the proteasome.Cryptogein affects expression of alpha3, alpha6 and beta1 20S proteasome subunits encoding genes in tobacco.Ghrelin induces apoptosis in colon adenocarcinoma cells via proteasome inhibition and autophagy induction.Immunoproteasome functions explained by divergence in cleavage specificity and regulation.Purification and characterization of the 20S proteasome from ostrich skeletal muscle.Genomic organization, localization and polymorphism of porcine PSMB10, a gene encoding the third beta-type proteasome subunit of 26S proteasome complex.
P2860
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P2860
Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Bovine spleen multicatalytic p ...... in properties and specificity.
@en
Bovine spleen multicatalytic p ...... in properties and specificity.
@nl
type
label
Bovine spleen multicatalytic p ...... in properties and specificity.
@en
Bovine spleen multicatalytic p ...... in properties and specificity.
@nl
prefLabel
Bovine spleen multicatalytic p ...... in properties and specificity.
@en
Bovine spleen multicatalytic p ...... in properties and specificity.
@nl
P2093
P2860
P356
P1476
Bovine spleen multicatalytic p ...... in properties and specificity.
@en
P2093
Kohanski RA
Orlowski M
P2860
P304
11824-11831
P356
10.1074/JBC.272.18.11824
P407
P577
1997-05-01T00:00:00Z