Molecular determinants of dofetilide block of HERG K+ channels.
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A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channelsThe antipsychotic drug chlorpromazine inhibits HERG potassium channelsMechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG DomainMolecular pathogenesis of long QT syndrome type 2State-dependent barium block of wild-type and inactivation-deficient HERG channels in Xenopus oocytesA structural basis for drug-induced long QT syndromeInhibition of HERG1 K(+) channels by the novel second-generation antihistamine mizolastineA molecular switch driving inactivation in the cardiac K+ channel HERGAntiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG K+ channels in parkinsonian discharges.Molecular determinants of gating at the potassium-channel selectivity filter.Molecular driving forces determining potassium channel slow inactivation.Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation.Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome.Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current.QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development.Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels.High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance.The molecular and ionic specificity of antiarrhythmic drug actions.Prospective validation of a comprehensive in silico hERG model and its applications to commercial compound and drug databases.Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore openingThe amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanismIn silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome.Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes.Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels.Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel.The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels.Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmiasA model of the interaction between N-type and C-type inactivation in Kv1.4 channels.Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel.A multipoint hydrogen-bond network underlying KcsA C-type inactivation.Inhibition of HERG channels stably expressed in a mammalian cell line by the antianginal agent perhexiline maleateInhibition of HERG potassium channels by the antimalarial agent halofantrineInhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241.Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome.The Link between Inactivation and High-Affinity Block of hERG1 ChannelsMolecular determinants of pentamidine-induced hERG trafficking inhibition.Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.Pore determinants of KCNQ3 K+ current expression.hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine.
P2860
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P2860
Molecular determinants of dofetilide block of HERG K+ channels.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Molecular determinants of dofetilide block of HERG K+ channels.
@en
Molecular determinants of dofetilide block of HERG K+ channels.
@nl
type
label
Molecular determinants of dofetilide block of HERG K+ channels.
@en
Molecular determinants of dofetilide block of HERG K+ channels.
@nl
prefLabel
Molecular determinants of dofetilide block of HERG K+ channels.
@en
Molecular determinants of dofetilide block of HERG K+ channels.
@nl
P2093
P356
P1433
P1476
Molecular determinants of dofetilide block of HERG K+ channels.
@en
P2093
P304
P356
10.1161/01.RES.82.3.386
P577
1998-02-01T00:00:00Z