Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signalingThe protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transductionGli proteins and the control of spinal-cord patterningA gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tubeKinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral stateEstablishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedbackDorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activityMorphogen rules: design principles of gradient-mediated embryo patterningMaking a grade: Sonic Hedgehog signalling and the control of neural cell fateSonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothenedOtx2 regulates subtype specification and neurogenesis in the midbrainATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signalingHomeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signallingThe transcriptional control of trunk neural crest induction, survival, and delaminationThe transcriptional repressor Glis2 is a novel binding partner for p120 cateninIntrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic SwitchesPax6 controls progenitor cell identity and neuronal fate in response to graded Shh signalingInhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndromeTranscriptional repression coordinates the temporal switch from motor to serotonergic neurogenesisSOX9 induces and maintains neural stem cellsGeneration of mice with functional inactivation of talpid3, a gene first identified in chickenA homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tubeDevelopment-on-chip: in vitro neural tube patterning with a microfluidic deviceA fluorescent reporter of caspase activity for live imaging.Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signallingAn amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates.Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.The specification of neuronal identity by graded Sonic Hedgehog signalling.Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube.Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversityRegulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites.An intuitive graphical visualization technique for the interrogation of transcriptome data.Limbs made to measure.SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factorsIn vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identityA theoretical framework for the regulation of Shh morphogen-controlled gene expressionCoordination of progenitor specification and growth in mouse and chick spinal cordReduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling
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description
Senior group leader at the Francis Crick Institute in London
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onderzoeker
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հետազոտող
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name
James Briscoe
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James Briscoe
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James Briscoe
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James Briscoe
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James Briscoe
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type
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James Briscoe
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James Briscoe
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James Briscoe
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James Briscoe
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James Briscoe
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James Briscoe
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James Briscoe
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James Briscoe
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James Briscoe
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James Briscoe
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