New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.
about
Coordination programming of photofunctional moleculesFluorescent approaches for understanding interactions of ligands with G protein coupled receptorsRecent developments in adenosine receptor ligands and their potential as novel drugsPharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand-receptor complexes.The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells.Application of BRET to monitor ligand binding to GPCRs.Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands.Fluorescent ligands for adenosine receptors.Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates.Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonistBiophysical Detection of Diversity and Bias in GPCR Function.Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors.Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism.Synthesis of BODIPY derivatives substituted with various bioconjugatable linker groups: a construction kit for fluorescent labeling of receptor ligands.Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes.Bridged bis-BODIPYs: their synthesis, structures and properties.BODIPY(®) FL histamine as a new modality for quantitative detection of histamine receptor upregulation upon IgE sensitization in murine bone marrow-derived mast cells.
P2860
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P2860
New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
@zh-hans
2007年学术文章
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2007年学术文章
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2007年學術文章
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2007年學術文章
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name
New fluorescent adenosine A1-r ...... omains of single living cells.
@en
New fluorescent adenosine A1-r ...... omains of single living cells.
@nl
type
label
New fluorescent adenosine A1-r ...... omains of single living cells.
@en
New fluorescent adenosine A1-r ...... omains of single living cells.
@nl
prefLabel
New fluorescent adenosine A1-r ...... omains of single living cells.
@en
New fluorescent adenosine A1-r ...... omains of single living cells.
@nl
P2093
P50
P356
P1476
New fluorescent adenosine A1-r ...... domains of single living cells
@en
P2093
Andrew S Yates
Clare L Dale
Michael W George
Richard J Middleton
Yolande Cordeaux
P304
P356
10.1021/JM061279I
P407
P577
2007-01-24T00:00:00Z