Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus. - Test2 - elhamkhani - TriplyDB

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus.

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus.

http://www.wikidata.org/entity/Q50940528

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Pathways leading to an immunological disease: systemic lupus erythematosus.Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases Regulatory T Cell Responses to High-Dose Methylprednisolone in Active Systemic Lupus Erythematosus Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells.Metabolic Factors that Contribute to Lupus Pathogenesis Stabilizing human regulatory T cells for tolerance inducing immunotherapy.T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis.Plasmablasts with a mucosal phenotype contribute to plasmacytosis in SLE.Promoting Immune Regulation in Type 1 Diabetes Using Low-Dose Interleukin-2.Empowering Regulatory T Cells in Autoimmunity.Regulatory T Cells: Central Concepts from Ontogeny to Therapy.T cells in Systemic Lupus Erythematosus.Regulatory T Cells in SLE: Biology and Use in Treatment.Beyond pan-B-cell-directed therapy - new avenues and insights into the pathogenesis of SLE.Low-Dose IL-2 in the Treatment of Lupus.Systemic lupus erythematosus in the light of the regulatory effects of galectin-1 on T-cell function.Brief Report: CD4+ T Cells From Patients With Systemic Lupus Erythematosus Respond Poorly to Exogenous Interleukin-2.T cells and autoimmune kidney disease.Dysregulated Lymphoid Cell Populations in Mouse Models of Systemic Lupus Erythematosus.The rise of IL-2 therapy - a picture beyond Treg cells.Two separate effects contribute to regulatory T cell defect in systemic lupus erythematosus patients and their unaffected relatives.Regulatory T cells in Acute and Chronic Kidney Diseases.From pathogenesis to novel therapies in the treatment of primary biliary cholangitis.The Role of the Transcription Factor Ets1 in Lupus and Other Autoimmune Diseases.Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus-Derived T Cells.Therapeutic potential of low-dose IL-2 in immune thrombocytopenia: An analysis of 3 cases.Regulatory T Cells: Molecular and Cellular Basis for Immunoregulation.Baseline IL-2 and the AIH score can predict the response to standard therapy in paediatric autoimmune hepatitis.Autoimmunity and primary immunodeficiency: two sides of the same coin?Low CD25 on autoreactive Tregs impairs tolerance via low dose IL-2 and antigen delivery.Recent developments in systemic lupus erythematosus pathogenesis and applications for therapy.Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25high FOXP3+ Regulatory T Cells As a Basis for a Regulatory T Cell-Based Adoptive Immunotherapy.Low regulatory T cell and high IL-17 mRNA expression in a mouse Graves' disease model.Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases.Low-dose IL-2 therapy - a complex scenario that remains to be further explored.Clinical trials: The rise of IL-2 therapy - a novel biologic treatment for SLE.Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus.Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis.

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Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus.

http://www.wikidata.org/entity/Q50940528

description

2015 nî lūn-bûn

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2015年學術文章

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name

Low-dose interleukin-2 selecti ...... systemic lupus erythematosus.

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Low-dose interleukin-2 selecti ...... systemic lupus erythematosus.

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Low-dose interleukin-2 selecti ...... systemic lupus erythematosus.

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Low-dose interleukin-2 selecti ...... systemic lupus erythematosus.

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Low-dose interleukin-2 selecti ...... systemic lupus erythematosus.

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ANNRHEUMDIS-2015-207776

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Annals of the Rheumatic Diseases

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Low-dose interleukin-2 selecti ...... systemic lupus erythematosus.

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Andreas Radbruch

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Angelika Rose

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Anika Klaus

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Caroline von Spee-Mayer

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Dimas Abdirama

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Falk Hiepe

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Jens Y Humrich

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Philipp Enghard

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Tobias Alexander

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P2860

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

Control of regulatory T cell development by the transcription factor Foxp3

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

Regulatory T cells and immune tolerance

Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.

The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells.

Low-dose daily interleukin-2 immunotherapy: accelerating immune restoration and expanding HIV-specific T-cell immunity without toxicity.

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1407-1415

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Gabriela Riemekasten

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Birgit Sawitzki

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2015-08-31T00:00:00Z

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26324847

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