about
ADCY5 couples glucose to insulin secretion in human isletsThe HNF-1 target collectrin controls insulin exocytosis by SNARE complex formationMutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humansPalmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic isletsPer-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretionGLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein BimClass II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cellsChanges in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection.The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection.Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling.Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes.Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.Protective unfolded protein response in human pancreatic beta cells transplanted into mice.Automated assessment of β-cell area and density per islet and patient using TMEM27 and BACE2 immunofluorescence staining in human pancreatic β-cells.Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cellsThe human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.Nova1 is a master regulator of alternative splicing in pancreatic beta cells.A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets.β-Cell inflammation in human type 2 diabetes and the role of autophagy.Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expressionCoxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients.C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells.Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.Evidence of β-Cell Dedifferentiation in Human Type 2 DiabetesChanges in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.The beta-cell in human type 2 diabetes.Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis.TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells.Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis.Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia.MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion.RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction.
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Lorella Marselli
@ast
Lorella Marselli
@en
Lorella Marselli
@es
Lorella Marselli
@nl
Lorella Marselli
@sl
type
label
Lorella Marselli
@ast
Lorella Marselli
@en
Lorella Marselli
@es
Lorella Marselli
@nl
Lorella Marselli
@sl
prefLabel
Lorella Marselli
@ast
Lorella Marselli
@en
Lorella Marselli
@es
Lorella Marselli
@nl
Lorella Marselli
@sl
P106
P1153
55922091300
6701741987
P21
P31
P496
0000-0002-6698-2962