P185
Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry.The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolorStructure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sitesStructural constraints on protein self-processing in L-aspartate- -decarboxylaseCrystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativitypH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric studyDesign, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinasesInhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction IntermediateApplication of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetaseA Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial ChemistryCrystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymesOptimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate SynthetaseStructural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosisFrom Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1Using a Fragment-Based Approach To Target Protein-Protein InteractionsStructure ofEscherichia coliaspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formationOvercoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series TargetingMycobacterium tuberculosisCYP121Integrated biophysical approach to fragment screening and validation for fragment-based lead discoveryTargeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B BromodomainHigh-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based AssayApplication of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121Threonine 57 is required for the post-translational activation ofEscherichia coliaspartate α-decarboxylaseValidating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch SpecificallyEngineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51
P50
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P50
description
British biological chemist
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Brits scheikundige
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chimiste britannique
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químicu británicu
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شیمیدان بریتانیایی
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كيميائي من المملكة المتحدة
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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Chris Abell
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P1006
P214
P244
P1006
P101
P106
P1153
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P1207
n2005097513
P184
P2070
christopher-abell-12842
P21
P213
0000 0001 1626 0147