Population pharmacokinetic and pharmacodynamic modeling of different formulations of ONO-5334, cathepsin K inhibitor, in Caucasian and Japanese postmenopausal females.

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Morning vs evening dosing of the cathepsin K inhibitor ONO-5334: effects on bone resorption in postmenopausal women in a randomized, phase 1 trial

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Population pharmacokinetic and pharmacodynamic modeling of different formulations of ONO-5334, cathepsin K inhibitor, in Caucasian and Japanese postmenopausal females.

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2013 nî lūn-bûn

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2013年の論文

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Population pharmacokinetic and ...... panese postmenopausal females.

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Population pharmacokinetic and ...... panese postmenopausal females.

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Population pharmacokinetic and ...... panese postmenopausal females.

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Population pharmacokinetic and ...... panese postmenopausal females.

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Population pharmacokinetic and ...... panese postmenopausal females.

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Population pharmacokinetic and ...... panese postmenopausal females.

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Ichiro Ieiri

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Maria Small

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Michiyo Ohyama

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Mikio Ogawa

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Naoki Honda

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Shinichi Nagase

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Steve Deacon

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Takeo Umemura

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Tomoya Ohno

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P2860

Simultaneous vs. sequential analysis for population PK/PD data I: best-case performance.

Preanalytical variability of biochemical markers of bone turnover.

Comparison of four basic models of indirect pharmacodynamic responses

A semimechanistic and mechanistic population PK-PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis.

Serum and urine bone resorption markers and pharmacokinetics of the cathepsin K inhibitor ONO-5334 after ascending single doses in post menopausal women.

An update on biomarkers of bone turnover and their utility in biomedical research and clinical practice.

Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls.

Are population pharmacokinetic and/or pharmacodynamic models adequately evaluated? A survey of the literature from 2002 to 2004.

Cathepsin K inhibitors: a novel target for osteoporosis therapy.

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23-34

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scholarly article

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10.1002/JCPH.186

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Chihiro Hasegawa

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2013-10-10T00:00:00Z

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257649022

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24115072

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Population pharmacokinetic and pharmacodynamic modeling of different formulations of ONO-5334, cathepsin K inhibitor, in Caucasian and Japanese postmenopausal females.

about

P2860

P2860

Population pharmacokinetic and pharmacodynamic modeling of different formulations of ONO-5334, cathepsin K inhibitor, in Caucasian and Japanese postmenopausal females.

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