A first-in-human phase I study to evaluate the MEK1/2 inhibitor, cobimetinib, administered daily in patients with advanced solid tumors.
about
A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor.Risk of peripheral edema in cancer patients treated with MEK inhibitors: a systematic review and meta-analysis of clinical trials.Signaling pathways as therapeutic targets in biliary tract cancer.Cobimetinib.Mechanisms and strategies to overcome resistance to molecularly targeted therapy for melanoma.BRAF inhibitors: resistance and the promise of combination treatments for melanoma.MEK inhibitors under development for treatment of non-small-cell lung cancer.Current Development Status of MEK Inhibitors.A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types.
P2860
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P2860
A first-in-human phase I study to evaluate the MEK1/2 inhibitor, cobimetinib, administered daily in patients with advanced solid tumors.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
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2016年学术文章
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2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
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2016年學術文章
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name
A first-in-human phase I study ...... ts with advanced solid tumors.
@en
A first-in-human phase I study ...... ts with advanced solid tumors.
@nl
type
label
A first-in-human phase I study ...... ts with advanced solid tumors.
@en
A first-in-human phase I study ...... ts with advanced solid tumors.
@nl
prefLabel
A first-in-human phase I study ...... ts with advanced solid tumors.
@en
A first-in-human phase I study ...... ts with advanced solid tumors.
@nl
P2093
P2860
P1476
A first-in-human phase I study ...... nts with advanced solid tumors
@en
P2093
A Dimitrios Colevas
Alex Adjei
Angela Shen
Branimir I Sikic
Hsin-Ju Hsieh
Iris T Chan
Jonathan W Goldman
Lee S Rosen
Patricia LoRusso
P2860
P2888
P304
P356
10.1007/S10637-016-0374-3
P577
2016-07-16T00:00:00Z