about
Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthaseAllosterically gated enzyme dynamics in the cysteine synthase complex regulate cysteine biosynthesis in Arabidopsis thalianaStructural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting ComplexProfiling of Flavonol Derivatives for the Development of Antitrypanosomatidic DrugsStructure and dynamics of the membrane-bound cytochrome P450 2C9Organism-adapted specificity of the allosteric regulation of pyruvate kinase in lactic acid bacteriaHomology modeling of the Abl-SH3 domain.ProSAT: functional annotation of protein 3D structures.The ins and outs of cytochrome P450s.Bridging from molecular simulation to biochemical networks.qPIPSA: relating enzymatic kinetic parameters and interaction fields.Molecular simulations reveal that the long range fluctuations of human DPP III change upon ligand binding.Three steps to gold: mechanism of protein adsorption revealed by Brownian and molecular dynamics simulations.Prediction of homoprotein and heteroprotein complexes by protein docking and template-based modeling: A CASP-CAPRI experimentProSAT+: visualizing sequence annotations on 3D structure.Structural changes in cytochrome P-450cam effected by the binding of the enantiomers (1R)-camphor and (1S)-camphor.Importance of explicit salt ions for protein stability in molecular dynamics simulation.Multicopy molecular dynamics simulations suggest how to reconcile crystallographic and product formation data for camphor enantiomers bound to cytochrome P-450cam.Comparative structural and energetic analysis of WW domain-peptide interactions.MolSurfer: A macromolecular interface navigator.Diffusion and association processes in biological systems: theory, computation and experiment.How do substrates enter and products exit the buried active site of cytochrome P450cam? 1. Random expulsion molecular dynamics investigation of ligand access channels and mechanisms.Exceptionally stable salt bridges in cytochrome P450cam have functional roles.Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.A unique profilin-actin interface is important for malaria parasite motilityDiffusion of hydrophobin proteins in solution and interactions with a graphite surface.Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine.Visualization of macromolecular structures.The interaction properties of the human Rab GTPase family--comparative analysis reveals determinants of molecular binding selectivityDo mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling?Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors.Elusive recognition determinants for ubiquitination.TRAPP webserver: predicting protein binding site flexibility and detecting transient binding pockets.Translational repression of thymidylate synthase by targeting its mRNA.Biomolecular diffusional association.SYCAMORE--a systems biology computational analysis and modeling research environment.Redesigning dehalogenase access tunnels as a strategy for degrading an anthropogenic substrate.Dynamics of CYP51: implications for function and inhibitor design.Long range Debye-Hückel correction for computation of grid-based electrostatic forces between biomacromolecules.
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description
Professor at Heidelberg University
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wetenschapper
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հետազոտող
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name
Rebecca C Wade
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Rebecca C Wade
@en
Rebecca C Wade
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Rebecca C Wade
@nl
Rebecca C Wade
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type
label
Rebecca C Wade
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Rebecca C Wade
@en
Rebecca C Wade
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Rebecca C Wade
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Rebecca C Wade
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altLabel
Rebecca C Wade
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prefLabel
Rebecca C Wade
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Rebecca C Wade
@en
Rebecca C Wade
@es
Rebecca C Wade
@nl
Rebecca C Wade
@sl
P214
P106
P1960
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P21
P214
P2456
P31
P496
0000-0001-5951-8670
P734
P735
P7859
viaf-317148880