Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

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The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions.Structural insights into DNA degradation by human mitochondrial nuclease MGME1

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Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

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2018 nî lūn-bûn

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2018年学术文章

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Mice lacking the mitochondrial ...... s without developing progeria.

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Mice lacking the mitochondrial ...... s without developing progeria.

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Item

label

Mice lacking the mitochondrial ...... s without developing progeria.

@en

Mice lacking the mitochondrial ...... s without developing progeria.

@nl

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Mice lacking the mitochondrial ...... s without developing progeria.

@en

Mice lacking the mitochondrial ...... s without developing progeria.

@nl

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Mice lacking the mitochondrial ...... ns without developing progeria

@en

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Caren Dirksen-Schwanenland

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Jay P Uhler

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Marie-Lune Simard

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Min Jiang

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Paola Loguercio Polosa

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Stanka Matic

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Xinping Li

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P2860

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion

TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein

Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion

Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia

Primer removal during mammalian mitochondrial DNA replication

Mitochondrial genetics

Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria

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s41467-018-03552-x

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scholarly article

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10.1038/S41467-018-03552-X

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English

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Aleksandra Filipovska

Nils-Göran Larsson

Dusanka Milenkovic

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2018-03-23T00:00:00Z

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29572490

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5865154

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Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

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P2860

P2860

Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

description

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type

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P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932