Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.
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NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomasInvolvement of midkine in neuroblastoma tumourigenesisThe zebrafish as a model for studying neuroblastomaFocal DNA copy number changes in neuroblastoma target MYCN regulated genesResearch progress of neuroblastoma related gene variations.The prenatal origins of cancerCombined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models.Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma.Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cellsNeuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours.Intrinsic susceptibility MRI identifies tumors with ALKF1174L mutation in genetically-engineered murine models of high-risk neuroblastomaNeuroblastoma: developmental biology, cancer genomics and immunotherapy.Mosaic zebrafish transgenesis for functional genomic analysis of candidate cooperative genes in tumor pathogenesis.A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies.Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma.Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer.Neuroblastoma and MYCNForetinib is a potent inhibitor of oncogenic ROS1 fusion proteins.ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma.BET bromodomain protein inhibition is a therapeutic option for medulloblastoma.Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.Identification of different ALK mutations in a pair of neuroblastoma cell lines established at diagnosis and relapse.The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis.New insights into the genetics of neuroblastoma.New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK.Recent insights into the biology of neuroblastoma.Mechanisms of neuroblastoma regressionNeuroblastoma models for insights into tumorigenesis and new therapies.Tackling Crizotinib Resistance: The Pathway from Drug Discovery to the Pediatric Clinic.Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase.MiR-34a deficiency accelerates medulloblastoma formation in vivo.miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin.The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinoma.Recipient leukocyte infusion enhances the local and systemic graft-versus-neuroblastoma effect of allogeneic bone marrow transplantation in mice.Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma.Oral Metronomic Topotecan Sensitizes Crizotinib Antitumor Activity in ALKF1174L Drug-Resistant Neuroblastoma Preclinical Models.Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma.A Novel EGFR Extracellular Domain Mutant, EGFRΔ768, Possesses Distinct Biological and Biochemical Properties in NeuroblastomaSmac mimetic LCL161 supports neuroblastoma chemotherapy in a drug class-dependent manner and synergistically interacts with ALK inhibitor TAE684 in cells with ALK mutation F1174L.Zebrafish Leucocyte tyrosine kinase controls iridophore establishment, proliferation and survival.
P2860
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P2860
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.
@en
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.
@nl
type
label
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.
@en
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.
@nl
prefLabel
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.
@en
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.
@nl
P2093
P2860
P50
P1476
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice
@en
P2093
Andrea Odersky
Angelika Eggert
Annette Künkele
Annika Spruessel
Candy Kumps
Johannes H Schulte
Katharina König
Pieter Mestdagh
Reinhard Büttner
Roland T Ullrich
P2860
P304
P356
10.1126/SCITRANSLMED.3003967
P407
P50
P577
2012-07-01T00:00:00Z