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Identification of hammerhead ribozymes in all domains of life reveals novel structural variationsThe odyssey of a regulated transcript.Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud.Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.Identification of a conserved RNA motif essential for She2p recognition and mRNA localization to the yeast bud.Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.The principal role of Ku in telomere length maintenance is promotion of Est1 association with telomeresUsing fluorescent proteins to study mRNA trafficking in living cells.Protrusion-localized STAT3 mRNA promotes metastasis of highly metastatic hepatocellular carcinoma cells in vitroFission yeast and other yeasts as emergent models to unravel cellular aging in eukaryotes.Control of cytoplasmic mRNA localization.Telomeric noncoding RNA: telomeric repeat-containing RNA in telomere biology.An E2F/miR-20a autoregulatory feedback loop.Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrityDesigning small multiple-target artificial RNAs.Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.Special focus on telomeres and telomerase.Modeling active RNA structures using the intersection of conformational space: application to the lead-activated ribozyme.Nuclear shuttling of She2p couples ASH1 mRNA localization to its translational repression by recruiting Loc1p and Puf6p.Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2.Live cell imaging of telomerase RNA dynamics reveals cell cycle-dependent clustering of telomerase at elongating telomeres.Cell cycle-dependent spatial segregation of telomerase from sites of DNA damage.Local activation of yeast ASH1 mRNA translation through phosphorylation of Khd1p by the casein kinase Yck1p.Live-cell imaging of budding yeast telomerase RNA and TERRA.Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres.[Telomerase biogenesis: a journey to the end of chromosomes].Effect of structural modifications on the activity of the leadzymeStructural elements required for the localization of ASH1 mRNA and of a green fluorescent protein reporter particle in vivoAsymmetric sorting of ash1p in yeast results from inhibition of translation by localization elements in the mRNAKnowing when to let goVisualizing mRNAs in fixed and living yeast cellsStochastic and reversible aggregation of mRNA with expanded CUG-triplet repeats
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Pascal Chartrand
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P106
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P21
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