about
Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivityPharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progressionNovel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implicationsInhibition of basal FGF receptor signaling by dimeric Grb2A landscape of driver mutations in melanomaMeasurement of the formation of complexes in tyrosine kinase-mediated signal transductionStpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI.The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinasesThe hidden thermodynamics of a zinc fingerH-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact proteinStructure, dynamics, and binding thermodynamics of the v-Src SH2 domain: implications for drug designH-NS forms a superhelical protein scaffold for DNA condensationRigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor TriggeringStructure and Interactions of the Human Programmed Cell Death 1 ReceptorDiscovery and characterization of novel selective inhibitors of carbonic anhydrase IXObserved bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2The role of water in sequence-independent ligand binding by an oligopeptide transporter proteinIdentification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperoneRT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 NefExpression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivatorT(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26Conformational changes in the AAA ATPase p97-p47 adaptor complexGrb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancerPlakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activityExpression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma.Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion.Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems.Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling.Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function.Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat.Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.Probing cocaine-antibody interactions in buffer and human serumIdentification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation.Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.Two EGF molecules contribute additively to stabilization of the EGFR dimer(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus.Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains.Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditionsA requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans.
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Q24310274-E429B216-75BE-4F7E-860A-5244E0849DD9Q24314416-A0216738-B5C2-4B8F-95FC-789BA249FE33Q24318683-E99333A5-7BC6-4287-A0ED-FD0705F6000BQ24338779-F6C5F190-9DC9-46DE-B0D3-2B72CA5929C0Q24603357-46F32B3E-EF2B-4AE6-814A-43686E484385Q24654723-10CDE55D-134A-4858-93EA-02E3C3A83725Q24811273-47F3067E-EF65-4B17-BC9C-E40D35B7DFA2Q27630908-7D523A76-D890-4A7D-8E9A-8DF0425057A2Q27638231-9E85A7B1-6047-4EDE-B5FC-C881CC1D54EBQ27640081-E1A2C5EF-7144-41F6-B9E0-591743278231Q27650763-8F0C30EE-21C3-4710-8586-C103F79A8E02Q27664196-976E9AE9-7597-4D61-B319-B305314EA7A8Q27666303-04B10BD4-15CA-4D32-83DF-C6A97E3AA1CDQ27676419-1A08766A-4102-4AB2-B4AC-FCF6433507C4Q27695870-C932110E-5038-4DF7-B3DF-75999161AE89Q27696569-381DBAA6-D0D0-4C8D-8225-2C5DC2C75419Q27734061-F286E139-62FE-46AC-A691-35BEDDD19922Q27740876-68C98F05-17E8-443B-B685-E1875BE01917Q27765703-8ECAB37D-29BB-4674-BCC6-BCDC5E275D42Q28191274-5873B55F-E9B4-499B-8056-81A0D8BC0D59Q28264988-36B61CF7-FC4B-413F-BCBD-864B7E06A73FQ28306308-D3528EC1-B341-4FFB-937A-E9B13E956B29Q28389726-72DC993B-DE8E-4AB9-92D5-8A186855CFA3Q28539201-7027B0D6-188D-4863-9444-325608DB533EQ30009050-40DC11D9-F062-48CC-BE92-E53364647621Q30009495-978911E2-59D1-4812-B756-BCA480A93A67Q30010095-692184B3-F4CE-4A75-902B-D57D93899679Q30155909-5E060EEF-F30B-4ACD-9536-1118CC525464Q30157135-7FA4F751-5CD0-40A0-922E-FED66B553FB1Q30164615-87F0DE1B-0CD5-4E02-A82F-B61A4E3974CBQ30832199-4B29177A-E2C0-4070-A06B-D4E5E5764C17Q31034089-69E832B6-643D-4C99-9F19-E9831E95CE86Q31079066-D31F15A2-0C1B-4A86-B603-41222B11C69AQ33280444-8833B5EA-1F71-4A02-99F8-1CDAD6D1C655Q33761415-6CE4B14B-971C-417A-B7A8-93B210EAA391Q33885990-FDF5D1B6-F9C4-43AC-AEA7-D9F17946EA68Q33949875-173892ED-4056-4BB2-A530-69283A18977CQ34132153-BBF09101-26E6-4A5C-8CF7-420106516D17Q34319793-A8F4D6EE-222F-42F4-B69D-071E14991D39Q34664878-8388DE06-3AC4-4DE3-90DC-05A153EC6B65
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description
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John E Ladbury
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John E Ladbury
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John E Ladbury
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John E Ladbury
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P214
P244
P106
P1153
7004818585
P2031
1990-01-01T00:00:00Z
P21
P213
0000 0001 1700 3660
P214
P244
P31
P496
0000-0002-6328-7200
P735
P7859
lccn-n97801936