about
Guidelines for the use and interpretation of assays for monitoring autophagyActivation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destructionInvolvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signallingRGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domainResistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activityRgs13 constrains early B cell responses and limits germinal center sizesEvidence for a short form of RGS3 preferentially expressed in the human heartAdditional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activationTumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting proteinRGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunitsTRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagyB lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis.RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III.TLR4 signaling augments B lymphocyte migration and overcomes the restriction that limits access to germinal center dark zones.Defective chemokine signal integration in leukocytes lacking activator of G protein signaling 3 (AGS3)Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-κB activation and enhancing autophagyG13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription.Implications of non-canonical G-protein signaling for the immune systemTumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2).Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness.Normal autophagic activity in macrophages from mice lacking Gαi3, AGS3, or RGS19.The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes.Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential.Lymph node B lymphocyte trafficking is constrained by anatomy and highly dependent upon chemoattractant desensitization.G-protein-coupled receptor signaling, RGS proteins, and lymphocyte function.Regulator of G-protein signaling 3 isoform 1 (PDZ-RGS3) enhances canonical Wnt signaling and promotes epithelial mesenchymal transitionIL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa.Chemoattractant receptor signaling and the control of lymphocyte migration.Inhibition of regulator of G protein signaling function by two mutant RGS4 proteinsActivator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection.Potential role for a regulator of G protein signaling (RGS3) in gonadotropin-releasing hormone (GnRH) stimulated desensitization.MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages.RETRACTED: GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38The influence of sphingosine-1-phosphate receptor signaling on lymphocyte trafficking: how a bioactive lipid mediator grew up from an "immature" vascular maturation factor to a "mature" mediator of lymphocyte behavior and function.The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanismRegulation of immune function by G protein-coupled receptors, trimeric G proteins, and RGS proteins.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
John H Kehrl
@nl
John H Kehrl
@sl
John H. Kehrl
@en
John H. Kehrl
@es
type
label
John H Kehrl
@nl
John H Kehrl
@sl
John H. Kehrl
@en
John H. Kehrl
@es
prefLabel
John H Kehrl
@nl
John H Kehrl
@sl
John H. Kehrl
@en
John H. Kehrl
@es
P106
P1153
7005076525
P31
P496
0000-0002-6526-159X