Bloom's syndrome: evidence for an increased mutation frequency in vivo.
about
Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiaeEvidence for increased in vivo mutation and somatic recombination in Bloom's syndromeSlx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3.Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometric assay at HLA-A locusStage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome geneMutation of the murine Bloom's syndrome gene produces global genome destabilizationImmunological lesions in human uracil DNA glycosylase: association with Bloom syndrome.Joining of linear plasmid DNA is reduced and error-prone in Bloom's syndrome cells.Molecular evidence that homologous recombination occurs in proliferating human somatic cells.High frequency of large spontaneous deletions of DNA in tumor-derived CHEF cellsLoss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice.Constitutional hyperrecombinability and its consequences.Somatic cell gene mutations in humans: biomarkers for genotoxicity.Bloom syndrome: a single complementation group defines patients of diverse ethnic origin.Chromosomal breakage in human spermatozoa, a heterozygous effect of the Bloom syndrome mutation.Spontaneous rearrangement of integrated simian virus 40 DNA in nine transformed rodent cell lines.Human somatic mutation assays as biomarkers of carcinogenesis.DNA repair: the link between primary immunodeficiency and cancer.SOS response in mammalian cells.Multimerization domains are associated with apparent strand exchange activity in BLM and WRN DNA helicases.Somatic intragenic recombination within the mutated locus BLM can correct the high sister-chromatid exchange phenotype of Bloom syndrome cells.Low-sister-chromatid-exchange Bloom syndrome cell lines: an important new tool for mapping the basic genetic defect in Bloom syndrome and for unraveling the biology of human tumor development.Is the initial event in carcinogenesis an enhancement of the mutation rate?Two types of DNA ligase I activity in lymphoblastoid cells from patients with Bloom's syndrome.
P2860
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P2860
Bloom's syndrome: evidence for an increased mutation frequency in vivo.
description
1983 nî lūn-bûn
@nan
1983年の論文
@ja
1983年学术文章
@wuu
1983年学术文章
@zh-cn
1983年学术文章
@zh-hans
1983年学术文章
@zh-my
1983年学术文章
@zh-sg
1983年學術文章
@yue
1983年學術文章
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1983年學術文章
@zh-hant
name
Bloom's syndrome: evidence for an increased mutation frequency in vivo.
@en
Bloom's syndrome: evidence for an increased mutation frequency in vivo.
@nl
type
label
Bloom's syndrome: evidence for an increased mutation frequency in vivo.
@en
Bloom's syndrome: evidence for an increased mutation frequency in vivo.
@nl
prefLabel
Bloom's syndrome: evidence for an increased mutation frequency in vivo.
@en
Bloom's syndrome: evidence for an increased mutation frequency in vivo.
@nl
P2093
P356
P1433
P1476
Bloom's syndrome: evidence for an increased mutation frequency in vivo.
@en
P2093
P304
P356
10.1126/SCIENCE.6879180
P407
P577
1983-08-01T00:00:00Z