about
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activationTRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.The paracaspase MALT1: biological function and potential for therapeutic inhibitionPKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytesEquine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinaseEquine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue, bcl-10Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activationTRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaBMalt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes.Monoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interfaceCARMA1, BCL-10 and MALT1 in lymphocyte development and activation.Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.Molecular cloning of porcine T cell receptor alpha, beta, gamma and delta chains using polymerase chain reaction fragments of the constant regions.Post-translational modifications regulate distinct functions of CARMA1 and BCL10.CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies.Viral inhibitor of apoptosis vFLIP/K13 protects endothelial cells against superoxide-induced cell death.Multifunctional roles for MALT1 in T-cell activation.Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase.The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles.Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis.Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell SignalosomeDlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation.Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis.Molecular mechanism of T-cell activation: role of protein tyrosine kinases in antigen receptor-mediated signal transduction.The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex.Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell deathActivating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas.MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells.IKKα takes control of canonical NF-κB activation.Anti-apoptotic strategies of lymphotropic virusesInhibition of fas death signals by FLIPsBcl10
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Margot Thome
@ast
Margot Thome
@en
Margot Thome
@es
Margot Thome
@nl
Margot Thome
@sl
type
label
Margot Thome
@ast
Margot Thome
@en
Margot Thome
@es
Margot Thome
@nl
Margot Thome
@sl
prefLabel
Margot Thome
@ast
Margot Thome
@en
Margot Thome
@es
Margot Thome
@nl
Margot Thome
@sl
P1053
F-8167-2011
P106
P21
P31
P496
0000-0002-5656-2139