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sameAs
Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus MethyltransferaseStructures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common ThemePfit Is a Structurally Novel Crohn's Disease-Associated SuperantigenStructural basis of conformational transitions in the active site and 80′s loop in the FK506-binding protein FKBP12Novel Broad Spectrum Inhibitors Targeting the Flavivirus MethyltransferaseA conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease.Influenza virus pleiomorphy characterized by cryoelectron tomographyVisualization of the two-step fusion process of the retrovirus avian sarcoma/leukosis virus by cryo-electron tomography.Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change.The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell binding.Cysteines flanking the internal fusion peptide are required for the avian sarcoma/leukosis virus glycoprotein to mediate the lipid mixing stage of fusion with high efficiency.The flavivirus protease as a target for drug discovery.S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferaseCoupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor ProteinsDNA forms of arboviral RNA genomes are generated following infection in mosquito cell cultures.Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase.Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease.Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Matthew Brecher
@ast
Matthew Brecher
@en
Matthew Brecher
@es
Matthew Brecher
@nl
Matthew Brecher
@sl
type
label
Matthew Brecher
@ast
Matthew Brecher
@en
Matthew Brecher
@es
Matthew Brecher
@nl
Matthew Brecher
@sl
prefLabel
Matthew Brecher
@ast
Matthew Brecher
@en
Matthew Brecher
@es
Matthew Brecher
@nl
Matthew Brecher
@sl
P106
P1153
22940076700
P31
P496
0000-0003-1151-2290