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Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity.GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cellsTime and Antigen-Stimulation History Influence Memory CD8 T Cell Bystander ResponsesTCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cellsCritical requirement of GABPalpha for normal T cell developmentDifferentiation and persistence of memory CD8(+) T cells depend on T cell factor 1IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells.The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation.The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses.β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation.Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection.LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells.Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors.The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentationCritical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.CD8+ T Lymphocyte Self-Renewal during Effector Cell Determination.IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivoCD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions.Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.Sox2 modulates Lef-1 expression during airway submucosal gland development.Fidelity of a BAC-EGFP transgene in reporting dynamic expression of IL-7Rα in T cells.From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells.Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection.Cutting Edge: β-Catenin-Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions.Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections.GABPbeta2 is dispensible for normal lymphocyte development but moderately affects B cell responses.The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1.The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy.Lef1-dependent hypothalamic neurogenesis inhibits anxiety.Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells.Identification of hematopoietic-specific regulatory elements from the CD45 gene and use for lentiviral tracking of transplanted cells.The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.MLL4 keeps Foxp3 in the loop.Stabilization of NF-κB-Inducing Kinase Suppresses MLL-AF9-Induced Acute Myeloid Leukemia.Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1.
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wetenschapper
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հետազոտող
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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Hai-Hui Xue
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P106
P1153
7202516829
P31
P496
0000-0002-9163-7669