about
The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respirationInhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic miceDiscriminative Prediction of A-To-I RNA Editing Events from DNA SequenceNNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells.Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetesPyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretionMolecularly imprinted polymers in capillary electrochromatography: recent developments and future trends.Molecularly imprinted polymer formats for capillary electrochromatography.Deletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice.The impact of Roux-en-Y gastric bypass surgery on normal metabolism in a porcine modelMetabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2)Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells.Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity.Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines.Development and optimization of a metabolomic method for analysis of adherent cell cultures.Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13).Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive DiabetesGastric bypass improves β-cell function and increases β-cell mass in a porcine model.Nanoparticles as pseudostationary phase in capillary electrochromatography/ESI-MS.Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans.Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.Selectivity toward multiple predetermined targets in nanoparticle capillary electrochromatography.Ultra-high-performance supercritical fluid chromatography with quadrupole-time-of-flight mass spectrometry (UHPSFC/QTOF-MS) for analysis of lignin-derived monomeric compounds in processed lignin samples.Metabolite profiling of obese individuals before and after a one year weight loss program.Changes in glucose-elicited blood metabolite responses following weight loss and long term weight maintenance in obese individuals with impaired glucose tolerance.Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 (GLP-1) is Governed by an Activated Glutamate Dehydrogenase.The pathogenetic role of β-cell mitochondria in type 2 diabetes.Probiotic fruit beverages with different polyphenol profiles attenuated early insulin response.Continuous full filling capillary electrochromatography: nanoparticle synthesis and evaluation.Continuous full filling capillary electrochromatography: chromatographic performance and reproducibility.Nanoparticle-based continuous full filling capillary electrochromatography/electrospray ionization-mass spectrometry for separation of neutral compounds.Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype.Metabolite profile deviations in an oral glucose tolerance test-a comparison between lean and obese individuals.Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.Unique and Shared Metabolic Regulation in Clonal β-Cells and Primary Islets Derived From Rat Revealed by Metabolomics Analysis.Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Peter Spégel
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Peter Spégel
@en
Peter Spégel
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Peter Spégel
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Peter Spégel
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type
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Peter Spégel
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Peter Spégel
@en
Peter Spégel
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Peter Spégel
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Peter Spégel
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prefLabel
Peter Spégel
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Peter Spégel
@en
Peter Spégel
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Peter Spégel
@nl
Peter Spégel
@sl
P106
P21
P31
P496
0000-0002-6092-2387