about
'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase.Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease.Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors.New insights into aminoglycoside antibiotics and derivatives.In silico design and search for acetylcholinesterase inhibitors in Alzheimer's disease with a suitable pharmacokinetic profile and low toxicity.Synthetic 1,2,3-triazole-linked glycoconjugates bind with high affinity to human galectin-3.Antibodies against mucin-based glycopeptides affect Trypanosoma cruzi cell invasion and tumor cell viability.α-Selective glycosylation affords mucin-related GalNAc amino acids and diketopiperazines active on Trypanosoma cruzi.Click chemistry oligomerisation of azido-alkyne-functionalised galactose accesses triazole-linked linear oligomers and macrocycles that inhibit Trypanosoma cruzi macrophage invasion.Synthesis of neamine-based pseudodisaccharides as potential vestibulotoxic agents to treat vertigo in Ménière's disease.Practical synthesis of the 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-beta-D-glucosides of Fmoc-serine and Fmoc-threonine and their benzyl esters.Novel aryl β-aminocarbonyl derivatives as inhibitors of Trypanosoma cruzi trypanothione reductase: binding mode revised by docking and GRIND2-based 3D-QSAR procedures.Homology modeling and molecular interaction field studies of alpha-glucosidases as a guide to structure-based design of novel proposed anti-HIV inhibitors.Chemical and chemoenzymatic synthesis of glycosyl-amino acids and glycopeptides related to Trypanosoma cruzi mucins.Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.1,2,3-Triazole-based analogue of benznidazole displays remarkable activity against Trypanosoma cruzi.CuAAC click chemistry with N-propargyl 1,5-dideoxy-1,5-imino-D-gulitol and N-propargyl 1,6-dideoxy-1,6-imino-D-mannitol provides access to triazole-linked piperidine and azepane pseudo-disaccharide iminosugars displaying glycosidase inhibitory propeGlycoclusters presenting lactose on calix[4]arene cores display trypanocidal activityApplication of copper(I)-catalysed azide/alkyne cycloaddition (CuAAC) ‘click chemistry’ in carbohydrate drug and neoglycopolymer synthesisCyclooligomerisation of azido-alkyne-functionalised sugars: synthesis of 1,6-linked cyclic pseudo-galactooligosaccharides and assessment of their sialylation by Trypanosoma cruzi trans-sialidaseNovel glucopyranoside C2-derived 1,2,3-triazoles displaying selective inhibition of O-GlcNAcase (OGA)Design, synthesis and the effect of 1,2,3-triazole sialylmimetic neoglycoconjugates on Trypanosoma cruzi and its cell surface trans-sialidaseSynthesis and trypanocidal activity of 1,4-bis-(3,4,5-trimethoxy-phenyl)-1,4-butanediol and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediolDehydromonocrotaline inhibits mitochondrial complex I. A potential mechanism accounting for hepatotoxicity of monocrotalineMolecular dynamics, density functional, ADMET predictions, virtual screening, and molecular interaction field studies for identification and evaluation of novel potential CDK2 inhibitors in cancer therapyNeamine and 2-deoxystreptamine neomycin derivatives exhibit antinociceptive activity in rat models of phasic, incision and neuropathic painDesign, synthesis and enzymatic evaluation of 3-O-substituted aryl β-D-galactopyranosides as inhibitors of Trypanosoma cruzi trans-sialidaseHighly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease
P50
Q33545529-7A9EDCD6-1462-469C-8AE6-53388CEAC751Q34484792-521BD350-2DD7-49E7-B879-E91574037189Q35918929-4A92662D-E975-49A3-B989-E758131AACDEQ36800434-C006A3AE-F30B-49AC-B9D4-050A7EC3E8A6Q37894710-7AD0EBB1-AF60-4051-8B73-7E1BAE00B54EQ38298998-97D76C41-D1FA-4767-93D5-6AD75A932E3BQ38985680-68B60F70-0318-433B-9E77-4D2862F6A76FQ39193591-77840783-36FC-42A0-9A36-6DCC3B183F35Q42690254-F7DAAF03-4381-4D8C-8BC4-A5EF10FB0732Q43898776-1F5DFA3B-AE29-4340-9740-42ABEFDC52F6Q44411176-F822A379-09F6-4F19-BEB3-61EABBE0438FQ45927357-E1B236F5-B79A-49A8-8A36-DA08862B8722Q46630846-7350C7EA-5AF2-461A-889A-9BF99E543DB0Q46895525-DDB297CE-9907-436E-8D23-5BE9FAC6AA8EQ50019292-4FE1592B-926F-4CCB-82C8-24F2085D8A84Q50922866-D9D5AD9F-0083-4319-8D81-95A3EC90F830Q53159603-F9A64D17-A921-422B-B17F-FA07BE573A7FQ57572178-EBB0617A-C2F1-4189-9700-F0D6BF0CA91EQ57572185-0B905C5B-3B4D-406B-98D6-FBA5D6FC1FF4Q57572189-C4852D12-78CC-4A75-92EF-02759704E9E9Q58605143-7ABFDA41-7310-43BA-8AE2-36B63AC03451Q58849752-572DC9D9-7DDB-4DB3-BCDF-A08CCCB1114EQ80110176-88146BE4-4E3D-479B-9164-787DA5AE01DFQ80721591-6BAD48FC-B089-4499-B030-DFDCCFD527B3Q81775502-3E70D0ED-47B6-42DD-86D6-B93718359396Q86173396-209E46D3-874E-4642-92EB-A717483148F4Q87642750-21199A30-53E3-48DA-8834-105A200EE1AEQ91593163-F8E564AC-60BE-4BE9-A40A-C974B37F67CC
P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Ivone Carvalho
@ast
Ivone Carvalho
@en
Ivone Carvalho
@es
Ivone Carvalho
@nl
Ivone Carvalho
@sl
type
label
Ivone Carvalho
@ast
Ivone Carvalho
@en
Ivone Carvalho
@es
Ivone Carvalho
@nl
Ivone Carvalho
@sl
prefLabel
Ivone Carvalho
@ast
Ivone Carvalho
@en
Ivone Carvalho
@es
Ivone Carvalho
@nl
Ivone Carvalho
@sl
P106
P21
P31
P496
0000-0002-2028-777X