about
Development of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrateEvaluation of GSH adducts of adrenaline in biological samples.Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes.Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes.The mixture of "ecstasy" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations."Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity.Several transport systems contribute to the intestinal uptake of Paraquat, modulating its cytotoxic effects.3,4-Methylenedioxypyrovalerone (MDPV): in vitro mechanisms of hepatotoxicity under normothermic and hyperthermic conditions.Quantification of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5), a newly synthetized P-glycoprotein inducer/activator, in biological samples: method development and validation.Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy.Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.New Thermoresponsive Eyedrop Formulation Containing Ibuprofen Loaded-Nanostructured Lipid Carriers (NLC): Development, Characterization and Biocompatibility Studies.Piperazine designer drugs induce toxicity in cardiomyoblast h9c2 cells through mitochondrial impairment.RBE4 cells are highly resistant to paraquat-induced cytotoxicity: studies on uptake and efflux mechanisms.Mechanisms of P-gp inhibition and effects on membrane fluidity of a new rifampicin derivative, 1,8-dibenzoyl-rifampicin.Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP.In vitro study of P-glycoprotein induction as an antidotal pathway to prevent cytotoxicity in Caco-2 cells.First report on Cydonia oblonga Miller anticancer potential: differential antiproliferative effect against human kidney and colon cancer cells.Human cancer cell antiproliferative and antioxidant activities of Juglans regia L.Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity.Cocaine-induced kidney toxicity: an in vitro study using primary cultured human proximal tubular epithelial cells.Development and validation of a GC/IT-MS method for simultaneous quantitation of para and meta-synephrine in biological samples.P-glycoprotein activity in human Caucasian male lymphocytes does not follow its increased expression during aging.Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes.Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies.PEGylated PLGA nanoparticles as a smart carrier to increase the cellular uptake of a coumarin-based monoamine oxidase B inhibitorMitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic ImpairmentInduction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquatEffect of colchicine on P-glycoprotein expression and activity in Caco2 cellsInfluence of aging and prostatic disease in the expression and activity of P-glycoprotein in human lymphocytesP-glycoprotein induction as a cellular protection tool against xenobiotics toxicityQuantification of doping compounds in faecal samples from racing pigeons, by liquid chromatography-tandem mass spectrometryPiperazine designer drugs are cytotoxic to human neuroblastoma SH-SY5Y cellsOxidation Process of Adrenaline in Freshly Isolated Rat Cardiomyocytes: Formation of Adrenochrome, Quinoproteins, and GSH AdductNewly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: , , and StudiesThe Use of Feathers from Racing Pigeons for Doping Control PurposesP-glycoprotein activation by 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) in rat distal ileum: ex vivo and in vivo studiesBoosting Drug Discovery for Parkinson's: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Renata Silva
@ast
Renata Silva
@en
Renata Silva
@es
Renata Silva
@nl
Renata Silva
@sl
type
label
Renata Silva
@ast
Renata Silva
@en
Renata Silva
@es
Renata Silva
@nl
Renata Silva
@sl
prefLabel
Renata Silva
@ast
Renata Silva
@en
Renata Silva
@es
Renata Silva
@nl
Renata Silva
@sl
P106
P1153
7201604534
P21
P31
P496
0000-0001-9962-7548