about
Structural basis and specificity of human otubain 1-mediated deubiquitinationPost-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasionDetection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor developmentMTH1 inhibition eradicates cancer by preventing sanitation of the dNTP poolDifferential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairmentA photoreactive small-molecule probe for 2-oxoglutarate oxygenases.Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probesThe human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages.A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.Factors contributing to neuromuscular impairment and sarcopenia during aging.Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection.Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia.Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells.Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells.The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition.The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia.Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle.Photoactivable peptides for identifying enzyme–substrate and protein–protein interactionsFluorescence-based active site probes for profiling deubiquitinating enzymesIron load and redox stress in skeletal muscle of aged ratsCell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization DynamicsThe histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiationMuscle atrophy and regeneration associated with behavioural loss and recovery of function after sciatic nerve crushImpact of vitamin D and vitamin D receptor TaqI polymorphism in primary human myoblastsSmall-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
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description
researcher
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wetenschapper
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հետազոտող
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name
Mikael Altun
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Mikael Altun
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Mikael Altun
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Mikael Altun
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Mikael Altun
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type
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Mikael Altun
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Mikael Altun
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Mikael Altun
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Mikael Altun
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Mikael Altun
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prefLabel
Mikael Altun
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Mikael Altun
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Mikael Altun
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Mikael Altun
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Mikael Altun
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P106
P1153
8157977300
P31
P496
0000-0002-6937-6124