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ADCY5 couples glucose to insulin secretion in human isletsThe mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretionLipotoxicity disrupts incretin-regulated human β cell connectivityThe transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult miceLanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imagingRemote control of glucose homeostasis in vivo using photopharmacology.Incretin-modulated beta cell energetics in intact islets of Langerhans.Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility.Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cellsDivergent effects of liraglutide, exendin-4, and sitagliptin on beta-cell mass and indicators of pancreatitis in a mouse model of hyperglycaemiaOptical control of insulin release using a photoswitchable sulfonylureaThe Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in miceBiologically targeted probes for Zn(2+): a diversity oriented modular "click-SNAr-click" approach†Electronic supplementary information (ESI) available: Full experimental details including characterisation of all novel compounds can be found in the ELKB1 and AMPK differentially regulate pancreatic β-cell identity.Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1Dual-modal magnetic resonance/fluorescent zinc probes for pancreatic β-cell mass imaging.Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.Rfx6 maintains the functional identity of adult pancreatic β cells.Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cellsThe Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets.Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in RatsChronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell FunctionOver-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia.Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon productionMolecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion.MiRNAs in β-Cell Development, Identity, and Disease.Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene.Minireview: intraislet regulation of insulin secretion in humans.Use of genetically encoded sensors to monitor cytosolic ATP/ADP ratio in living cells.The role of microRNAs in the pancreatic differentiation of pluripotent stem cells.Dorothy Hodgkin Lecture 2014. Understanding genes identified by genome-wide association studies for type 2 diabetes.Beta cell connectivity in pancreatic islets: a type 2 diabetes target?Hypothalamic glucagon signals through the KATP channels to regulate glucose production.
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researcher, ORCID id # 0000-0001-6360-0343
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Guy A. Rutter
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