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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Primary skin fibroblasts as a model of Parkinson's diseaseLoss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition.Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.Loss of PINK1 impairs stress-induced autophagy and cell survivalNeuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injuryPINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane.Restriction of trophic factors and nutrients induces PARKIN expressionBrain-to-stomach transfer of α-synuclein via vagal preganglionic projections.Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice.Mammalian ataxin-2 modulates translation control at the pre-initiation complex via PI3K/mTOR and is induced by starvation.Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1.Subthalamic lesion or levodopa treatment rescues giant GABAergic currents of PINK1-deficient striatum.Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels.LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylationGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Michael Klinkenberg
@ast
Michael Klinkenberg
@en
Michael Klinkenberg
@es
Michael Klinkenberg
@nl
type
label
Michael Klinkenberg
@ast
Michael Klinkenberg
@en
Michael Klinkenberg
@es
Michael Klinkenberg
@nl
prefLabel
Michael Klinkenberg
@ast
Michael Klinkenberg
@en
Michael Klinkenberg
@es
Michael Klinkenberg
@nl
P214
P106
P1153
24329627200
P214
P31
P496
0000-0002-0241-4712
P735
P7859
viaf-273118364