about
Rotating with the brakes on and other unresolved features of the vacuolar ATPaseFlexibility within the rotor and stators of the vacuolar H+-ATPaseThe benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme targetThe use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy.The changing landscape of membrane protein structural biology through developments in electron microscopy.Methods to account for movement and flexibility in cryo-EM data processing.PA1b inhibitor binding to subunits c and e of the vacuolar ATPase reveals its insecticidal mechanismStructure of the vacuolar H+-ATPase rotary motor reveals new mechanistic insightsThe potential use of single-particle electron microscopy as a tool for structure-based inhibitor design.The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery.Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure.Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.Spherical-supported membranes as platforms for screening against membrane protein targets.X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery.Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined statesCollection, pre-processing and on-the-fly analysis of data for high-resolution, single-particle cryo-electron microscopyStructural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalisStructure of a nascent membrane protein as it folds on the BAM complex
P50
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P50
description
researcher
@en
researcher
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wetenschapper
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հետազոտող
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name
Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
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Shaun Rawson
@sl
P106
P31
P496
0000-0002-2973-2630