about
Modulation of activity by Arg407: structure of a fungal α-1,2-mannosidase in complex with a substrate analogueCrystal complex structures reveal how substrate is bound in the -4 to the +2 binding sites of Humicola grisea Cel12A.Creating lactose phosphorylase enzymes by directed evolution of cellobiose phosphorylase.Development and application of a screening assay for glycoside phosphorylases.Engineering the acceptor specificity of trehalose phosphorylase for the production of trehalose analogs.Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors.Enzymatic Glycosylation of Phenolic Antioxidants: Phosphorylase-Mediated Synthesis and Characterization.CorNet: Assigning function to networks of co-evolving residues by automated literature mining.Engineering of cellobiose phosphorylase for glycoside synthesis.Enzymes for the biocatalytic production of rare sugars.Enzymatic glycosylation of small molecules: challenging substrates require tailored catalysts.An investigation of the substrate specificity of the xyloglucanase Cel74A from Hypocrea jecorina.Evaluation of automated nano-electrospray mass spectrometry in the determination of non-covalent protein-ligand complexes.Trehalose Analogues: Latest Insights in Properties and Biocatalytic Production.UDP-hexose 4-epimerases: a view on structure, mechanism and substrate specificity.A structural classification of carbohydrate epimerases: From mechanistic insights to practical applications.Enzymatic properties and substrate specificity of the trehalose phosphorylase from Caldanaerobacter subterraneus.Sucrose synthase: A unique glycosyltransferase for biocatalytic glycosylation process development.A quantitative indicator diagram for lytic polysaccharide monooxygenases reveals the role of aromatic surface residues in HjLPMO9A regioselectivity.Correlated positions in protein evolution and engineering.Crystallization and X-ray diffraction studies of cellobiose phosphorylase from Cellulomonas uda.Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors.Recombinant Expression of Trichoderma reesei Cel61A in Pichia pastoris: Optimizing Yield and N-terminal Processing.Identification of sucrose synthase in nonphotosynthetic bacteria and characterization of the recombinant enzymes.Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity.An imprinted cross-linked enzyme aggregate (iCLEA) of sucrose phosphorylase: combining improved stability with altered specificity.Synthesis of halogenated 4-quinolones and evaluation of their antiplasmodial activity.Sucrose phosphorylase as cross-linked enzyme aggregate: improved thermal stability for industrial applications.Enzymatic production of β-D-glucose-1-phosphate from trehalose.Increasing the thermostability of sucrose phosphorylase by multipoint covalent immobilization.Construction of cellobiose phosphorylase variants with broadened acceptor specificity towards anomerically substituted glucosides.Evaluation of (4-aminobutyloxy)quinolines as a novel class of antifungal agents.The quest for a thermostable sucrose phosphorylase reveals sucrose 6'-phosphate phosphorylase as a novel specificity.Characterization and mutational analysis of the UDP-Glc(NAc) 4-epimerase from Marinithermus hydrothermalis.Enzymatic production of alpha-D-galactose 1-phosphate by lactose phosphorolysis.Biocatalytic Synthesis of the Rare Sugar Kojibiose: Process Scale-Up and Application Testing.Glucosylglycerate Phosphorylase, an Enzyme with Novel Specificity Involved in Compatible Solute Metabolism.Sequence determinants of nucleotide binding in Sucrose Synthase: improving the affinity of a bacterial Sucrose Synthase for UDP by introducing plant residues.Screening of recombinant glycosyltransferases reveals the broad acceptor specificity of stevia UGT-76G1.Characterization of β-galactoside phosphorylases with diverging acceptor specificities.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Tom Desmet
@ast
Tom Desmet
@en
Tom Desmet
@es
Tom Desmet
@nl
type
label
Tom Desmet
@ast
Tom Desmet
@en
Tom Desmet
@es
Tom Desmet
@nl
prefLabel
Tom Desmet
@ast
Tom Desmet
@en
Tom Desmet
@es
Tom Desmet
@nl
P106
P108
P21
P31
P496
0000-0002-5788-3022