about
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrityInvolvement of membrane GRP78 in trophoblastic cell fusionCompound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signalingChemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose DeprivationMIDDAS-M: motif-independent de novo detection of secondary metabolite gene clusters through the integration of genome sequencing and transcriptome dataNovel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format.Screening and evaluation of new inhibitors of hepatic glucose production.Streptomyces tateyamensis sp. nov., Streptomyces marinus sp. nov. and Streptomyces haliclonae sp. nov., isolated from the marine sponge Haliclona sp.JBIR-22, an inhibitor for protein-protein interaction of the homodimer of proteasome assembly factor 3.Combinatorial synthesis of deoxyhexasaccharides related to the landomycin A sugar moiety, based on an orthogonal deprotection strategy.Complete genome sequence and expression profile of the commercial lytic enzyme producer Lysobacter enzymogenes M497-1Streptomyces aomiensis sp. nov., isolated from a soil sample using the membrane-filter method.A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp.Genome-based discovery of a novel membrane-bound 1,6-dihydroxyphenazine prenyltransferase from a marine actinomycete.Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole.New species of actinomycetes do not always produce new compounds with high frequency.Human telomerase reverse transcriptase and glucose-regulated protein 78 increase the life span of articular chondrocytes and their repair potential.Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.New chaetoglobosin derivatives, MBJ-0038, MBJ-0039 and MBJ-0040, isolated from the fungus Chaetomium sp. f24230.Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketidesNew acylated anthocyanins from purple yam and their antioxidant activity.(S)-stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor.Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.Terpene synthases are widely distributed in bacteria.Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis.Characterization of the biosynthetic gene cluster for maklamicin, a spirotetronate-class antibiotic of the endophytic Micromonospora sp. NBRC 110955.Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of actionDysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host.FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stabilityFANCJ couples replication past natural fork barriers with maintenance of chromatin structure.Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.tRNA-Dependent Aminoacylation of an Amino Sugar Intermediate in the Biosynthesis of a Streptothricin-Related Antibiotic.Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb.G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells.G-quadruplexes as potential therapeutic targets for embryonal tumors.Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin.Curromycin A as a GRP78 downregulator and a new cyclic dipeptide from Streptomyces sp.Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Kazuo Shin-ya
@ast
Kazuo Shin-ya
@en
Kazuo Shin-ya
@es
Kazuo Shin-ya
@nl
type
label
Kazuo Shin-ya
@ast
Kazuo Shin-ya
@en
Kazuo Shin-ya
@es
Kazuo Shin-ya
@nl
prefLabel
Kazuo Shin-ya
@ast
Kazuo Shin-ya
@en
Kazuo Shin-ya
@es
Kazuo Shin-ya
@nl
P106
P31
P496
0000-0002-4702-0661