about
Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activityFragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitorsHuman immunoglobulin E flexes between acutely bent and extended conformations.Missing Fragments: Detecting Cooperative Binding in Fragment-Based Drug DesignTwo-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitorsX-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactionsStructure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 InteractionStructure and substrate fingerprint of aminopeptidase P from Plasmodium falciparumIdentification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual ScreeningScreening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate.Circumventing the stability-function trade-off in an engineered FN3 domainFrom crystal to compound: structure-based antimalarial drug discovery.M1 aminopeptidases as drug targets: broad applications or therapeutic niche?X-ray crystal structure of cytochrome P450 monooxygenase CYP101J2 from Sphingobium yanoikuyae strain B2.Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.Crystal structure of a β-aminopeptidase from an Australian Burkholderia sp.Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2.Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Nyssa Drinkwater
@ast
Nyssa Drinkwater
@en
Nyssa Drinkwater
@es
Nyssa Drinkwater
@nl
type
label
Nyssa Drinkwater
@ast
Nyssa Drinkwater
@en
Nyssa Drinkwater
@es
Nyssa Drinkwater
@nl
prefLabel
Nyssa Drinkwater
@ast
Nyssa Drinkwater
@en
Nyssa Drinkwater
@es
Nyssa Drinkwater
@nl
P108
P106
P1153
14522291400
P31
P496
0000-0001-9165-7806