A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus
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Enhancer complexes located downstream of both human immunoglobulin Calpha genesThe HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombinationPosition and sequence conservation in Amniota of polymorphic enhancer HS1.2 within the palindrome of IgH 3'Regulatory RegionHistone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas.Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer.AID and somatic hypermutation.Pax5 (BSAP) regulates the murine immunoglobulin 3' alpha enhancer by suppressing binding of NF-alpha P, a protein that controls heavy chain transcription.Human antibodies from transgenic mice.The zebrafish IgH locus contains multiple transcriptional regulatory regions.Identification of 3' alpha-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation.Identification of USF as the ubiquitous murine factor that binds to and stimulates transcription from the immunoglobulin lambda 2-chain promoterCis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.The role of DNA breaks in genomic instability and tumorigenesis.The immunoglobulin heavy chain gene 3' enhancers induce Bcl2 deregulation and lymphomagenesis in murine B cells.c-myc hypermutation in Burkitt's lymphoma.Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancersThe plasmacytoma J558L lacks constitutively active NF-kappa B and is deficient in early response gene activationAn enhancer at the 3' end of the mouse immunoglobulin heavy chain locusA transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulinsCritical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci.Somatic hypermutation of an immunoglobulin mu heavy chain transgene.The 3' end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes.Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.Regulation of the replication of the murine immunoglobulin heavy chain gene locus: evaluation of the role of the 3' regulatory region.The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region.NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiationRegulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation.Transcription of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3' regulatory regionIn a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development.Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3' Regulatory Region.Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3' enhancer.Cis-acting regulatory sequences promote high-frequency gene conversion between repeated sequences in mammalian cells.Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma.Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector.Immunoglobulin E regulation in humans, 1989-1994.Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms.The importance of the 3'-enhancer region in immunoglobulin kappa gene expression.Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors
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P2860
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в березні 1990
@uk
name
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus
@en
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus
@nl
type
label
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus
@en
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus
@nl
prefLabel
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus
@en
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus
@nl
P2093
P356
P1433
P1476
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus
@en
P2093
Brüggemann M
Neuberger MS
Pettersson S
Williams GT
P2888
P304
P356
10.1038/344165A0
P407
P577
1990-03-01T00:00:00Z
P6179
1010295718